Epigenetics of breast cancer

Modifying role of environmental and bioactive food compounds

Donato F. Romagnolo, Kevin D. Daniels, Jonathan T. Grunwald, Stephan A. Ramos, Catherine R Propper, Ornella I. Selmin

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Scope: Reduced expression of tumor suppressor genes (TSG) increases the susceptibility to breast cancer. However, only a small percentage of breast tumors is related to family history and mutational inactivation of TSG. Epigenetics refers to non-mutational events that alter gene expression. Endocrine disruptors found in foods and drinking water may disrupt epigenetically hormonal regulation and increase breast cancer risk. This review centers on the working hypothesis that agonists of the aromatic hydrocarbon receptor (AHR), bisphenol A (BPA), and arsenic compounds, induce in TSG epigenetic signatures that mirror those often seen in sporadic breast tumors. Conversely, it is hypothesized that bioactive food components that target epigenetic mechanisms protect against sporadic breast cancer induced by these disruptors. Methods and results: This review highlights (i) overlaps between epigenetic signatures placed in TSG by AHR-ligands, BPA, and arsenic with epigenetic alterations associated with sporadic breast tumorigenesis; and (ii) potential opportunities for the prevention of sporadic breast cancer with food components that target the epigenetic machinery. Conclusions: Characterizing the overlap between epigenetic signatures elicited in TSG by endocrine disruptors with those observed in sporadic breast tumors may afford new strategies for breast cancer prevention with specific bioactive food components or diet.

Original languageEnglish (US)
Pages (from-to)1310-1329
Number of pages20
JournalMolecular Nutrition and Food Research
Volume60
Issue number6
DOIs
StatePublished - Jun 1 2016

Fingerprint

Epigenomics
epigenetics
breast neoplasms
tumor suppressor genes
Breast Neoplasms
Food
Tumor Suppressor Genes
Endocrine Disruptors
Aromatic Hydrocarbons
bisphenol A
endocrine-disrupting chemicals
aromatic hydrocarbons
arsenicals
Arsenicals
receptors
hormonal regulation
Arsenic
arsenic
Drinking Water
carcinogenesis

Keywords

  • Breast cancer
  • Cancer prevention
  • Endocrine disruptors
  • Epigenetics
  • Tumor suppressor genes

ASJC Scopus subject areas

  • Food Science
  • Biotechnology

Cite this

Epigenetics of breast cancer : Modifying role of environmental and bioactive food compounds. / Romagnolo, Donato F.; Daniels, Kevin D.; Grunwald, Jonathan T.; Ramos, Stephan A.; Propper, Catherine R; Selmin, Ornella I.

In: Molecular Nutrition and Food Research, Vol. 60, No. 6, 01.06.2016, p. 1310-1329.

Research output: Contribution to journalReview article

Romagnolo, Donato F. ; Daniels, Kevin D. ; Grunwald, Jonathan T. ; Ramos, Stephan A. ; Propper, Catherine R ; Selmin, Ornella I. / Epigenetics of breast cancer : Modifying role of environmental and bioactive food compounds. In: Molecular Nutrition and Food Research. 2016 ; Vol. 60, No. 6. pp. 1310-1329.
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