Epigenetic inheritance across the landscape

Amy V Whipple, Liza M. Holeski

Research output: Contribution to journalShort survey

10 Citations (Scopus)

Abstract

The study of epigenomic variation at the landscape-level in plants may add important insight to studies of adaptive variation. A major goal of landscape genomic studies is to identify genomic regions contributing to adaptive variation across the landscape. Heritable variation in epigenetic marks, resulting in transgenerational plasticity, can influence fitness-related traits. Epigenetic marks are influenced by the genome, the environment, and their interaction, and can be inherited independently of the genome. Thus, epigenomic variation likely influences the heritability of many adaptive traits, but the extent of this influence remains largely unknown. Here, we summarize the relevance of epigenetic inheritance to ecological and evolutionary processes, and review the literature on landscape-level patterns of epigenetic variation. Landscape-level patterns of epigenomic variation in plants generally show greater levels of isolation by distance and isolation by environment then is found for the genome, but the causes of these patterns are not yet clear. Linkage between the environment and epigenomic variation has been clearly shown within a single generation, but demonstrating transgenerational inheritance requires more complex breeding and/or experimental designs. Transgenerational epigenetic variation may alter the interpretation of landscape genomic studies that rely upon phenotypic analyses, but should have less influence on landscape genomic approaches that rely upon outlier analyses or genome-environment associations. We suggest that multi-generation common garden experiments conducted across multiple environments will allow researchers to understand which parts of the epigenome are inherited, as well as to parse out the relative contribution of heritable epigenetic variation to the phenotype.

Original languageEnglish (US)
Article number189
JournalFrontiers in Genetics
Volume7
Issue numberOCT
DOIs
StatePublished - Oct 25 2016

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Epigenomics
Genome
Breeding
Research Design
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Phenotype

Keywords

  • Adaptation
  • Epigenetics
  • Epigenome
  • Landscape genomics
  • Phenotype
  • Transgenerational plasticity

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Genetics(clinical)

Cite this

Epigenetic inheritance across the landscape. / Whipple, Amy V; Holeski, Liza M.

In: Frontiers in Genetics, Vol. 7, No. OCT, 189, 25.10.2016.

Research output: Contribution to journalShort survey

Whipple, Amy V ; Holeski, Liza M. / Epigenetic inheritance across the landscape. In: Frontiers in Genetics. 2016 ; Vol. 7, No. OCT.
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