Environmentally driven increases in type 2 diabetes and obesity in pima Indians and Non-Pimas in Mexico Over a 15-Year Period: The maycoba project

Julian Esparza-Romero, Mauro E. Valencia, Rene Urquidez-Romero, Lisa S. Chaudhari, Robert L. Hanson, William C. Knowler, Eric Ravussin, Peter H. Bennett, Leslie O. Schulz

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

OBJECTIVE The global epidemics of type 2 diabetes and obesity have been attributed to the interaction between lifestyle changes and genetic predisposition to these diseases. We compared the prevalences of type 2 diabetes and obesity in Mexican Pima Indians, presumed to have a high genetic predisposition to these diseases, to those in their non-Pima neighbors, both of whom over a 15-year period experienced a transition from a traditional to a more modern lifestyle. RESEARCH DESIGN AND METHODS Prevalence of diabetes, impaired fasting glucose, impaired glucose tolerance, and obesity in Mexican Pimas (n = 359) and non-Pima Mexicans (n = 251) were determined in 2010 using methods identical to those used in 1995. RESULTS During this 15-year period, age-adjusted diabetes prevalence was unchanged in Pima men (5.8% in 1995 vs. 6.1% in 2010) yet increased in non-Pima men from 0.0 to 8.6% (P < 0.05). Diabetes prevalence tended to increase in both Pima women (9.4 vs. 13.4%) and non-Pima women (4.8 vs. 9.5%). Age-adjusted prevalence of obesity increased significantly in all groups (6.6 vs. 15.7% in Pima men; 8.5 vs. 20.5% in non-Pima men; 18.9. vs 36.3%in Pima women; 29.5 vs. 42.9%in non-Pima women). CONCLUSIONS Type 2 diabetes prevalence increased between 1995 and 2010 in non-Pima men, and to a lesser degree in women of both groups, but it did not increase in Pima men. Prevalence of obesity increased among Pimas and non-Pimas of both sexes. These changes occurred concomitantly with an environmental transition from a traditional to a more modernized lifestyle.

Original languageEnglish (US)
Pages (from-to)2075-2082
Number of pages8
JournalDiabetes Care
Volume38
Issue number11
DOIs
StatePublished - Nov 2015

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Fingerprint Dive into the research topics of 'Environmentally driven increases in type 2 diabetes and obesity in pima Indians and Non-Pimas in Mexico Over a 15-Year Period: The maycoba project'. Together they form a unique fingerprint.

  • Cite this

    Esparza-Romero, J., Valencia, M. E., Urquidez-Romero, R., Chaudhari, L. S., Hanson, R. L., Knowler, W. C., Ravussin, E., Bennett, P. H., & Schulz, L. O. (2015). Environmentally driven increases in type 2 diabetes and obesity in pima Indians and Non-Pimas in Mexico Over a 15-Year Period: The maycoba project. Diabetes Care, 38(11), 2075-2082. https://doi.org/10.2337/dc15-0089