Environmentally driven increases in type 2 diabetes and obesity in pima Indians and Non-Pimas in Mexico Over a 15-Year Period: The maycoba project

Julian Esparza-Romero, Mauro E. Valencia, Rene Urquidez-Romero, Lisa S Chaudhari, Robert L. Hanson, William C. Knowler, Eric Ravussin, Peter H. Bennett, Leslie O. Schulz

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE The global epidemics of type 2 diabetes and obesity have been attributed to the interaction between lifestyle changes and genetic predisposition to these diseases. We compared the prevalences of type 2 diabetes and obesity in Mexican Pima Indians, presumed to have a high genetic predisposition to these diseases, to those in their non-Pima neighbors, both of whom over a 15-year period experienced a transition from a traditional to a more modern lifestyle. RESEARCH DESIGN AND METHODS Prevalence of diabetes, impaired fasting glucose, impaired glucose tolerance, and obesity in Mexican Pimas (n = 359) and non-Pima Mexicans (n = 251) were determined in 2010 using methods identical to those used in 1995. RESULTS During this 15-year period, age-adjusted diabetes prevalence was unchanged in Pima men (5.8% in 1995 vs. 6.1% in 2010) yet increased in non-Pima men from 0.0 to 8.6% (P <0.05). Diabetes prevalence tended to increase in both Pima women (9.4 vs. 13.4%) and non-Pima women (4.8 vs. 9.5%). Age-adjusted prevalence of obesity increased significantly in all groups (6.6 vs. 15.7% in Pima men; 8.5 vs. 20.5% in non-Pima men; 18.9. vs 36.3%in Pima women; 29.5 vs. 42.9%in non-Pima women). CONCLUSIONS Type 2 diabetes prevalence increased between 1995 and 2010 in non-Pima men, and to a lesser degree in women of both groups, but it did not increase in Pima men. Prevalence of obesity increased among Pimas and non-Pimas of both sexes. These changes occurred concomitantly with an environmental transition from a traditional to a more modernized lifestyle.

Original languageEnglish (US)
Pages (from-to)2075-2082
Number of pages8
JournalDiabetes Care
Volume38
Issue number11
DOIs
StatePublished - Nov 1 2015

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Potassium Iodide
Mexico
Type 2 Diabetes Mellitus
Obesity
Life Style
Genetic Predisposition to Disease
Glucose Intolerance
Fasting
Glucose

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

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Environmentally driven increases in type 2 diabetes and obesity in pima Indians and Non-Pimas in Mexico Over a 15-Year Period : The maycoba project. / Esparza-Romero, Julian; Valencia, Mauro E.; Urquidez-Romero, Rene; Chaudhari, Lisa S; Hanson, Robert L.; Knowler, William C.; Ravussin, Eric; Bennett, Peter H.; Schulz, Leslie O.

In: Diabetes Care, Vol. 38, No. 11, 01.11.2015, p. 2075-2082.

Research output: Contribution to journalArticle

Esparza-Romero, J, Valencia, ME, Urquidez-Romero, R, Chaudhari, LS, Hanson, RL, Knowler, WC, Ravussin, E, Bennett, PH & Schulz, LO 2015, 'Environmentally driven increases in type 2 diabetes and obesity in pima Indians and Non-Pimas in Mexico Over a 15-Year Period: The maycoba project', Diabetes Care, vol. 38, no. 11, pp. 2075-2082. https://doi.org/10.2337/dc15-0089
Esparza-Romero, Julian ; Valencia, Mauro E. ; Urquidez-Romero, Rene ; Chaudhari, Lisa S ; Hanson, Robert L. ; Knowler, William C. ; Ravussin, Eric ; Bennett, Peter H. ; Schulz, Leslie O. / Environmentally driven increases in type 2 diabetes and obesity in pima Indians and Non-Pimas in Mexico Over a 15-Year Period : The maycoba project. In: Diabetes Care. 2015 ; Vol. 38, No. 11. pp. 2075-2082.
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abstract = "OBJECTIVE The global epidemics of type 2 diabetes and obesity have been attributed to the interaction between lifestyle changes and genetic predisposition to these diseases. We compared the prevalences of type 2 diabetes and obesity in Mexican Pima Indians, presumed to have a high genetic predisposition to these diseases, to those in their non-Pima neighbors, both of whom over a 15-year period experienced a transition from a traditional to a more modern lifestyle. RESEARCH DESIGN AND METHODS Prevalence of diabetes, impaired fasting glucose, impaired glucose tolerance, and obesity in Mexican Pimas (n = 359) and non-Pima Mexicans (n = 251) were determined in 2010 using methods identical to those used in 1995. RESULTS During this 15-year period, age-adjusted diabetes prevalence was unchanged in Pima men (5.8{\%} in 1995 vs. 6.1{\%} in 2010) yet increased in non-Pima men from 0.0 to 8.6{\%} (P <0.05). Diabetes prevalence tended to increase in both Pima women (9.4 vs. 13.4{\%}) and non-Pima women (4.8 vs. 9.5{\%}). Age-adjusted prevalence of obesity increased significantly in all groups (6.6 vs. 15.7{\%} in Pima men; 8.5 vs. 20.5{\%} in non-Pima men; 18.9. vs 36.3{\%}in Pima women; 29.5 vs. 42.9{\%}in non-Pima women). CONCLUSIONS Type 2 diabetes prevalence increased between 1995 and 2010 in non-Pima men, and to a lesser degree in women of both groups, but it did not increase in Pima men. Prevalence of obesity increased among Pimas and non-Pimas of both sexes. These changes occurred concomitantly with an environmental transition from a traditional to a more modernized lifestyle.",
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T1 - Environmentally driven increases in type 2 diabetes and obesity in pima Indians and Non-Pimas in Mexico Over a 15-Year Period

T2 - The maycoba project

AU - Esparza-Romero, Julian

AU - Valencia, Mauro E.

AU - Urquidez-Romero, Rene

AU - Chaudhari, Lisa S

AU - Hanson, Robert L.

AU - Knowler, William C.

AU - Ravussin, Eric

AU - Bennett, Peter H.

AU - Schulz, Leslie O.

PY - 2015/11/1

Y1 - 2015/11/1

N2 - OBJECTIVE The global epidemics of type 2 diabetes and obesity have been attributed to the interaction between lifestyle changes and genetic predisposition to these diseases. We compared the prevalences of type 2 diabetes and obesity in Mexican Pima Indians, presumed to have a high genetic predisposition to these diseases, to those in their non-Pima neighbors, both of whom over a 15-year period experienced a transition from a traditional to a more modern lifestyle. RESEARCH DESIGN AND METHODS Prevalence of diabetes, impaired fasting glucose, impaired glucose tolerance, and obesity in Mexican Pimas (n = 359) and non-Pima Mexicans (n = 251) were determined in 2010 using methods identical to those used in 1995. RESULTS During this 15-year period, age-adjusted diabetes prevalence was unchanged in Pima men (5.8% in 1995 vs. 6.1% in 2010) yet increased in non-Pima men from 0.0 to 8.6% (P <0.05). Diabetes prevalence tended to increase in both Pima women (9.4 vs. 13.4%) and non-Pima women (4.8 vs. 9.5%). Age-adjusted prevalence of obesity increased significantly in all groups (6.6 vs. 15.7% in Pima men; 8.5 vs. 20.5% in non-Pima men; 18.9. vs 36.3%in Pima women; 29.5 vs. 42.9%in non-Pima women). CONCLUSIONS Type 2 diabetes prevalence increased between 1995 and 2010 in non-Pima men, and to a lesser degree in women of both groups, but it did not increase in Pima men. Prevalence of obesity increased among Pimas and non-Pimas of both sexes. These changes occurred concomitantly with an environmental transition from a traditional to a more modernized lifestyle.

AB - OBJECTIVE The global epidemics of type 2 diabetes and obesity have been attributed to the interaction between lifestyle changes and genetic predisposition to these diseases. We compared the prevalences of type 2 diabetes and obesity in Mexican Pima Indians, presumed to have a high genetic predisposition to these diseases, to those in their non-Pima neighbors, both of whom over a 15-year period experienced a transition from a traditional to a more modern lifestyle. RESEARCH DESIGN AND METHODS Prevalence of diabetes, impaired fasting glucose, impaired glucose tolerance, and obesity in Mexican Pimas (n = 359) and non-Pima Mexicans (n = 251) were determined in 2010 using methods identical to those used in 1995. RESULTS During this 15-year period, age-adjusted diabetes prevalence was unchanged in Pima men (5.8% in 1995 vs. 6.1% in 2010) yet increased in non-Pima men from 0.0 to 8.6% (P <0.05). Diabetes prevalence tended to increase in both Pima women (9.4 vs. 13.4%) and non-Pima women (4.8 vs. 9.5%). Age-adjusted prevalence of obesity increased significantly in all groups (6.6 vs. 15.7% in Pima men; 8.5 vs. 20.5% in non-Pima men; 18.9. vs 36.3%in Pima women; 29.5 vs. 42.9%in non-Pima women). CONCLUSIONS Type 2 diabetes prevalence increased between 1995 and 2010 in non-Pima men, and to a lesser degree in women of both groups, but it did not increase in Pima men. Prevalence of obesity increased among Pimas and non-Pimas of both sexes. These changes occurred concomitantly with an environmental transition from a traditional to a more modernized lifestyle.

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