Energy conserving thermoregulatory patterns and lower disease severity in a bat resistant to the impacts of white-nose syndrome

Marianne S. Moore, Kenneth A. Field, Melissa J. Behr, Gregory G. Turner, Morgan E. Furze, Daniel W.F. Stern, Paul R. Allegra, Sarah A. Bouboulis, Chelsey D. Musante, Megan E. Vodzak, Matthew E. Biron, Melissa B. Meierhofer, Winifred F. Frick, Jeffrey T Foster, Daryl Howell, Joseph A. Kath, Allen Kurta, Gerda Nordquist, Joseph S. Johnson, Thomas M. LilleyBenjamin W. Barrett, Dee Ann M. Reeder

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The devastating bat fungal disease, white-nose syndrome (WNS), does not appear to affect all species equally. To experimentally determine susceptibility differences between species, we exposed hibernating naïve little brown myotis (Myotis lucifugus) and big brown bats (Eptesicus fuscus) to the fungus that causes WNS, Pseudogymnoascus destructans (Pd). After hibernating under identical conditions, Pd lesions were significantly more prevalent and more severe in little brown myotis. This species difference in pathology correlates with susceptibility to WNS in the wild and suggests that survival is related to different host physiological responses. We observed another fungal infection, associated with neutrophilic inflammation, that was equally present in all bats. This suggests that both species are capable of generating a response to cold tolerant fungi and that Pd may have evolved mechanisms for evading host responses that are effective in at least some bat species. These host–pathogen interactions are likely mediated not just by host physiological responses, but also by host behavior. Pd-exposed big brown bats, the less affected species, spent more time in torpor than did control animals, while little brown myotis did not exhibit this change. This differential thermoregulatory response to Pd infection by big brown bat hosts may allow for a more effective (or less pathological) immune response to tissue invasion.

Original languageEnglish (US)
Pages (from-to)1-14
Number of pages14
JournalJournal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology
DOIs
StateAccepted/In press - Jun 8 2017

Fingerprint

disease severity
Fungi
bat
Nose
Chiroptera
Myotis
energy
Pathology
Animals
Mycoses
physiological response
Tissue
Torpor
fungus
torpor
fungal disease
fungi
resting periods
pathology
immune response

Keywords

  • Eptesicus fuscus
  • Fungal pathogen
  • Myotis lucifugus
  • Pseudogymnoascus destructans
  • Species differences
  • White-nose syndrome

ASJC Scopus subject areas

  • Physiology
  • Ecology, Evolution, Behavior and Systematics
  • Biochemistry
  • Animal Science and Zoology
  • Endocrinology

Cite this

Energy conserving thermoregulatory patterns and lower disease severity in a bat resistant to the impacts of white-nose syndrome. / Moore, Marianne S.; Field, Kenneth A.; Behr, Melissa J.; Turner, Gregory G.; Furze, Morgan E.; Stern, Daniel W.F.; Allegra, Paul R.; Bouboulis, Sarah A.; Musante, Chelsey D.; Vodzak, Megan E.; Biron, Matthew E.; Meierhofer, Melissa B.; Frick, Winifred F.; Foster, Jeffrey T; Howell, Daryl; Kath, Joseph A.; Kurta, Allen; Nordquist, Gerda; Johnson, Joseph S.; Lilley, Thomas M.; Barrett, Benjamin W.; Reeder, Dee Ann M.

In: Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology, 08.06.2017, p. 1-14.

Research output: Contribution to journalArticle

Moore, MS, Field, KA, Behr, MJ, Turner, GG, Furze, ME, Stern, DWF, Allegra, PR, Bouboulis, SA, Musante, CD, Vodzak, ME, Biron, ME, Meierhofer, MB, Frick, WF, Foster, JT, Howell, D, Kath, JA, Kurta, A, Nordquist, G, Johnson, JS, Lilley, TM, Barrett, BW & Reeder, DAM 2017, 'Energy conserving thermoregulatory patterns and lower disease severity in a bat resistant to the impacts of white-nose syndrome', Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology, pp. 1-14. https://doi.org/10.1007/s00360-017-1109-2
Moore, Marianne S. ; Field, Kenneth A. ; Behr, Melissa J. ; Turner, Gregory G. ; Furze, Morgan E. ; Stern, Daniel W.F. ; Allegra, Paul R. ; Bouboulis, Sarah A. ; Musante, Chelsey D. ; Vodzak, Megan E. ; Biron, Matthew E. ; Meierhofer, Melissa B. ; Frick, Winifred F. ; Foster, Jeffrey T ; Howell, Daryl ; Kath, Joseph A. ; Kurta, Allen ; Nordquist, Gerda ; Johnson, Joseph S. ; Lilley, Thomas M. ; Barrett, Benjamin W. ; Reeder, Dee Ann M. / Energy conserving thermoregulatory patterns and lower disease severity in a bat resistant to the impacts of white-nose syndrome. In: Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology. 2017 ; pp. 1-14.
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AU - Turner, Gregory G.

AU - Furze, Morgan E.

AU - Stern, Daniel W.F.

AU - Allegra, Paul R.

AU - Bouboulis, Sarah A.

AU - Musante, Chelsey D.

AU - Vodzak, Megan E.

AU - Biron, Matthew E.

AU - Meierhofer, Melissa B.

AU - Frick, Winifred F.

AU - Foster, Jeffrey T

AU - Howell, Daryl

AU - Kath, Joseph A.

AU - Kurta, Allen

AU - Nordquist, Gerda

AU - Johnson, Joseph S.

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