Emergence of resistance to fluoroquinolones and third-generation cephalosporins in Shigella flexneri subserotype 1c isolates from China

S. Qiu, X. Xu, Y. Wang, G. Yang, Z. Wang, H. Wang, L. Zhang, N. Liu, C. Chen, W. Liu, J. Li, W. Su, L. Jia, L. Wang, H. Jin, Paul S Keim, Z. Yuan, L. Huang, H. Song

Research output: Contribution to journalArticle

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Abstract

We report here on the first identification of Shigella flexneri subserotype 1c in China. We also report the emergence of resistance to ciprofloxacin and third-generation cephalosporins in this subserotype 1c for the first time. Isolates of seven strains circulating in China yielded three new sequence types and seven pulsed-field gel electrophoresis patterns, thus demonstrating the existence of high genetic diversity within the isolates. Overall, the seven isolates showed reduced susceptibility to ciprofloxacin; one isolate was ciprofloxacin resistant, whilst another developed resistance to ciprofloxacin, norfloxacin, cefotaxime and ceftriaxone.

Original languageEnglish (US)
JournalClinical Microbiology and Infection
Volume18
Issue number4
DOIs
StatePublished - Apr 2012

Fingerprint

Shigella flexneri
Fluoroquinolones
Cephalosporins
Ciprofloxacin
China
Norfloxacin
Cefotaxime
Ceftriaxone
Pulsed Field Gel Electrophoresis

Keywords

  • Banding pattern
  • Ciprofloxacin resistance
  • Genetic diversity
  • Sequence type
  • Shigella flexneri subserotype 1c

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Emergence of resistance to fluoroquinolones and third-generation cephalosporins in Shigella flexneri subserotype 1c isolates from China. / Qiu, S.; Xu, X.; Wang, Y.; Yang, G.; Wang, Z.; Wang, H.; Zhang, L.; Liu, N.; Chen, C.; Liu, W.; Li, J.; Su, W.; Jia, L.; Wang, L.; Jin, H.; Keim, Paul S; Yuan, Z.; Huang, L.; Song, H.

In: Clinical Microbiology and Infection, Vol. 18, No. 4, 04.2012.

Research output: Contribution to journalArticle

Qiu, S, Xu, X, Wang, Y, Yang, G, Wang, Z, Wang, H, Zhang, L, Liu, N, Chen, C, Liu, W, Li, J, Su, W, Jia, L, Wang, L, Jin, H, Keim, PS, Yuan, Z, Huang, L & Song, H 2012, 'Emergence of resistance to fluoroquinolones and third-generation cephalosporins in Shigella flexneri subserotype 1c isolates from China', Clinical Microbiology and Infection, vol. 18, no. 4. https://doi.org/10.1111/j.1469-0691.2012.03768.x
Qiu, S. ; Xu, X. ; Wang, Y. ; Yang, G. ; Wang, Z. ; Wang, H. ; Zhang, L. ; Liu, N. ; Chen, C. ; Liu, W. ; Li, J. ; Su, W. ; Jia, L. ; Wang, L. ; Jin, H. ; Keim, Paul S ; Yuan, Z. ; Huang, L. ; Song, H. / Emergence of resistance to fluoroquinolones and third-generation cephalosporins in Shigella flexneri subserotype 1c isolates from China. In: Clinical Microbiology and Infection. 2012 ; Vol. 18, No. 4.
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