Emergence of resistance to fluoroquinolones and third-generation cephalosporins in Shigella flexneri subserotype 1c isolates from China

S. Qiu; X. Xu; Y. Wang; G. Yang; Z. Wang; H. Wang; L. Zhang; N. Liu; C. Chen; W. Liu; J. Li; W. Su; L. Jia; L. Wang; H. Jin; P. Keim; Z. Yuan; L. Huang; H. Song

doi:10.1111/j.1469-0691.2012.03768.x

Emergence of resistance to fluoroquinolones and third-generation cephalosporins in Shigella flexneri subserotype 1c isolates from China

S. Qiu, X. Xu, Y. Wang, G. Yang, Z. Wang, H. Wang, L. Zhang, N. Liu, C. Chen, W. Liu, J. Li, W. Su, L. Jia, L. Wang, H. Jin, P. Keim, Z. Yuan, L. Huang, H. Song

Biological Sciences

Research output: Contribution to journal › Article

10 Scopus citations

Abstract

We report here on the first identification of Shigella flexneri subserotype 1c in China. We also report the emergence of resistance to ciprofloxacin and third-generation cephalosporins in this subserotype 1c for the first time. Isolates of seven strains circulating in China yielded three new sequence types and seven pulsed-field gel electrophoresis patterns, thus demonstrating the existence of high genetic diversity within the isolates. Overall, the seven isolates showed reduced susceptibility to ciprofloxacin; one isolate was ciprofloxacin resistant, whilst another developed resistance to ciprofloxacin, norfloxacin, cefotaxime and ceftriaxone.

Original language	English (US)
Pages (from-to)	E95-E98
Journal	Clinical Microbiology and Infection
Volume	18
Issue number	4
DOIs	https://doi.org/10.1111/j.1469-0691.2012.03768.x
State	Published - Apr 2012

Keywords

Banding pattern
Ciprofloxacin resistance
Genetic diversity
Sequence type
Shigella flexneri subserotype 1c

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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Qiu, S., Xu, X., Wang, Y., Yang, G., Wang, Z., Wang, H., Zhang, L., Liu, N., Chen, C., Liu, W., Li, J., Su, W., Jia, L., Wang, L., Jin, H., Keim, P., Yuan, Z., Huang, L., & Song, H. (2012). Emergence of resistance to fluoroquinolones and third-generation cephalosporins in Shigella flexneri subserotype 1c isolates from China. Clinical Microbiology and Infection, 18(4), E95-E98. https://doi.org/10.1111/j.1469-0691.2012.03768.x

Emergence of resistance to fluoroquinolones and third-generation cephalosporins in Shigella flexneri subserotype 1c isolates from China. / Qiu, S.; Xu, X.; Wang, Y.; Yang, G.; Wang, Z.; Wang, H.; Zhang, L.; Liu, N.; Chen, C.; Liu, W.; Li, J.; Su, W.; Jia, L.; Wang, L.; Jin, H.; Keim, P.; Yuan, Z.; Huang, L.; Song, H.

In: Clinical Microbiology and Infection, Vol. 18, No. 4, 04.2012, p. E95-E98.

Research output: Contribution to journal › Article

Qiu, S, Xu, X, Wang, Y, Yang, G, Wang, Z, Wang, H, Zhang, L, Liu, N, Chen, C, Liu, W, Li, J, Su, W, Jia, L, Wang, L, Jin, H, Keim, P, Yuan, Z, Huang, L & Song, H 2012, 'Emergence of resistance to fluoroquinolones and third-generation cephalosporins in Shigella flexneri subserotype 1c isolates from China', Clinical Microbiology and Infection, vol. 18, no. 4, pp. E95-E98. https://doi.org/10.1111/j.1469-0691.2012.03768.x

Qiu, S. ; Xu, X. ; Wang, Y. ; Yang, G. ; Wang, Z. ; Wang, H. ; Zhang, L. ; Liu, N. ; Chen, C. ; Liu, W. ; Li, J. ; Su, W. ; Jia, L. ; Wang, L. ; Jin, H. ; Keim, P. ; Yuan, Z. ; Huang, L. ; Song, H. / Emergence of resistance to fluoroquinolones and third-generation cephalosporins in Shigella flexneri subserotype 1c isolates from China. In: Clinical Microbiology and Infection. 2012 ; Vol. 18, No. 4. pp. E95-E98.

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abstract = "We report here on the first identification of Shigella flexneri subserotype 1c in China. We also report the emergence of resistance to ciprofloxacin and third-generation cephalosporins in this subserotype 1c for the first time. Isolates of seven strains circulating in China yielded three new sequence types and seven pulsed-field gel electrophoresis patterns, thus demonstrating the existence of high genetic diversity within the isolates. Overall, the seven isolates showed reduced susceptibility to ciprofloxacin; one isolate was ciprofloxacin resistant, whilst another developed resistance to ciprofloxacin, norfloxacin, cefotaxime and ceftriaxone.",

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AB - We report here on the first identification of Shigella flexneri subserotype 1c in China. We also report the emergence of resistance to ciprofloxacin and third-generation cephalosporins in this subserotype 1c for the first time. Isolates of seven strains circulating in China yielded three new sequence types and seven pulsed-field gel electrophoresis patterns, thus demonstrating the existence of high genetic diversity within the isolates. Overall, the seven isolates showed reduced susceptibility to ciprofloxacin; one isolate was ciprofloxacin resistant, whilst another developed resistance to ciprofloxacin, norfloxacin, cefotaxime and ceftriaxone.

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