Abstract
We report here on the first identification of Shigella flexneri subserotype 1c in China. We also report the emergence of resistance to ciprofloxacin and third-generation cephalosporins in this subserotype 1c for the first time. Isolates of seven strains circulating in China yielded three new sequence types and seven pulsed-field gel electrophoresis patterns, thus demonstrating the existence of high genetic diversity within the isolates. Overall, the seven isolates showed reduced susceptibility to ciprofloxacin; one isolate was ciprofloxacin resistant, whilst another developed resistance to ciprofloxacin, norfloxacin, cefotaxime and ceftriaxone.
| Original language | English (US) |
|---|---|
| Journal | Clinical Microbiology and Infection |
| Volume | 18 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 2012 |
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Keywords
- Banding pattern
- Ciprofloxacin resistance
- Genetic diversity
- Sequence type
- Shigella flexneri subserotype 1c
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases
Cite this
Emergence of resistance to fluoroquinolones and third-generation cephalosporins in Shigella flexneri subserotype 1c isolates from China. / Qiu, S.; Xu, X.; Wang, Y.; Yang, G.; Wang, Z.; Wang, H.; Zhang, L.; Liu, N.; Chen, C.; Liu, W.; Li, J.; Su, W.; Jia, L.; Wang, L.; Jin, H.; Keim, Paul S; Yuan, Z.; Huang, L.; Song, H.
In: Clinical Microbiology and Infection, Vol. 18, No. 4, 04.2012.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Emergence of resistance to fluoroquinolones and third-generation cephalosporins in Shigella flexneri subserotype 1c isolates from China
AU - Qiu, S.
AU - Xu, X.
AU - Wang, Y.
AU - Yang, G.
AU - Wang, Z.
AU - Wang, H.
AU - Zhang, L.
AU - Liu, N.
AU - Chen, C.
AU - Liu, W.
AU - Li, J.
AU - Su, W.
AU - Jia, L.
AU - Wang, L.
AU - Jin, H.
AU - Keim, Paul S
AU - Yuan, Z.
AU - Huang, L.
AU - Song, H.
PY - 2012/4
Y1 - 2012/4
N2 - We report here on the first identification of Shigella flexneri subserotype 1c in China. We also report the emergence of resistance to ciprofloxacin and third-generation cephalosporins in this subserotype 1c for the first time. Isolates of seven strains circulating in China yielded three new sequence types and seven pulsed-field gel electrophoresis patterns, thus demonstrating the existence of high genetic diversity within the isolates. Overall, the seven isolates showed reduced susceptibility to ciprofloxacin; one isolate was ciprofloxacin resistant, whilst another developed resistance to ciprofloxacin, norfloxacin, cefotaxime and ceftriaxone.
AB - We report here on the first identification of Shigella flexneri subserotype 1c in China. We also report the emergence of resistance to ciprofloxacin and third-generation cephalosporins in this subserotype 1c for the first time. Isolates of seven strains circulating in China yielded three new sequence types and seven pulsed-field gel electrophoresis patterns, thus demonstrating the existence of high genetic diversity within the isolates. Overall, the seven isolates showed reduced susceptibility to ciprofloxacin; one isolate was ciprofloxacin resistant, whilst another developed resistance to ciprofloxacin, norfloxacin, cefotaxime and ceftriaxone.
KW - Banding pattern
KW - Ciprofloxacin resistance
KW - Genetic diversity
KW - Sequence type
KW - Shigella flexneri subserotype 1c
UR - http://www.scopus.com/inward/record.url?scp=84862815785&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862815785&partnerID=8YFLogxK
U2 - 10.1111/j.1469-0691.2012.03768.x
DO - 10.1111/j.1469-0691.2012.03768.x
M3 - Article
C2 - 22329572
AN - SCOPUS:84862815785
VL - 18
JO - Clinical Microbiology and Infection
JF - Clinical Microbiology and Infection
SN - 1198-743X
IS - 4
ER -