Background and Purpose: Elderly individuals participate in resistance exercise to induce an anabolic response and grow muscle to help overcome functional deficits. It is thought that a muscle damage and inflammatory response to resistance exercise is a necessary prerequisite for an anabolic and muscle growth response. Methods: This is a descriptive study of 11 elderly individuals in rehabilitation who underwent a 2-3x/week high force resistance exercise that used eccentric contractions. Serum measures of muscle damage, inflammation, and an anabolic response are reported along with changes in muscle mass as measured with dual energy X-ray absorptiometry. Results: Negative work increased >3-fold during the 11 weeks of resistance exercise. There were no significant changes in the damage measure of serum creatine kinase (pretraining: 18.5 ± 1.2 Sigma units/ml; post-training: 19.2 ± 1.1 Sigma units/ml). Proinflammatory tumor necrosis factor-α values remained within normal range (<4.0 pg/ml) throughout the 11 weeks of training. A nonsignificant trend for an anabolic increase (65%) in insulin like growth factor-1 was noted along with a significant increase (6%) in thigh muscle mass. Conclusions: Neither damage, nor inflammation appear to be prerequisites for inducing anabolic and muscle growth responses in elderly individuals undergoing a high force resistance exercise with eccentric contractions.
|Original language||English (US)|
|Number of pages||7|
|Journal||Journal of Geriatric Physical Therapy|
|State||Published - 2007|
ASJC Scopus subject areas
- Geriatrics and Gerontology