Effects of α- and β-adrenergic agonists on Toxoplasma gondii infection in murine macrophages

Julie Getz, Fernando P. Monroy

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

We investigated the effects of α- and β-adrenergic receptor agonists on the ability of Toxoplasma gondii to infect and proliferate in cultured murine macrophages. Macrophages pretreated in vitro with varying concentrations of α- and β-adrenergic agonists and incubated with the RH strain of T. gondii did not result in a significant increase in the percentage of infected macrophages compared with negative controls. When parasites were pretreated with L-phenylephrine, an α-agonist, and L-isoproterenol, a β-agonist, before infection, there was no significant change in the percentage of infected macrophages. Clonidine, an α2-adrenergic agonist, led to a significant decrease in the number of infected macrophages at all concentrations tested. The effects of clonidine were blocked by yohimbine, a specific α2-adrenergic antagonist, but not by phentolamine, an α1-adrenergic antagonist. These results suggest that the antiparasitic effects exhibited by clonidine (α2-adrenergic agonist) are mediated through an α2-adrenoreceptor found on the surface of T. gondii.

Original languageEnglish (US)
Pages (from-to)193-195
Number of pages3
JournalJournal of Parasitology
Volume91
Issue number1
DOIs
StatePublished - Feb 1 2005

ASJC Scopus subject areas

  • Parasitology
  • Ecology, Evolution, Behavior and Systematics

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