Effect of microamperage stimulation on the rate of wound healing in rats: A histological study

D. J. Leffmann, D. A. Arnall, P. R. Holmgren, Mark W Cornwall

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background and Purpose. This study examined cutaneous wound healing after microamperage stimulation (MS). Subjects. Twelve female Sprague-Dawley rats were studied. Methods. The treatment (wound reduction) group (n=6) received 100 μA of current at 0.3 Hz on a 50% duty cycle for 2 hours a day for 14 days. The control group (n=6) received the same handling and electrode placement, but no current was applied. Wound size was measured daily following each treatment. Histological analysis included measurement of epithelial thickness, vascularity, and fibroblast density from tissue sections taken at the end of the experiment. Results. An analysis of variance showed no significant difference between the two groups with respect to the change in wound size over the 14 treatment days. A series of t tests showed no significant differences between the groups for any of the histological measurements. Conclusion and Discussion. The results of this study do not support the hypothesis that MS accelerates acute cutaneous wound healing.

Original languageEnglish (US)
Pages (from-to)195-200
Number of pages6
JournalPhysical Therapy
Volume74
Issue number3
StatePublished - 1994

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Wound Healing
Wounds and Injuries
Skin
Sprague Dawley Rats
Analysis of Variance
Electrodes
Fibroblasts
Control Groups

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Health Professions(all)
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Effect of microamperage stimulation on the rate of wound healing in rats : A histological study. / Leffmann, D. J.; Arnall, D. A.; Holmgren, P. R.; Cornwall, Mark W.

In: Physical Therapy, Vol. 74, No. 3, 1994, p. 195-200.

Research output: Contribution to journalArticle

Leffmann, D. J. ; Arnall, D. A. ; Holmgren, P. R. ; Cornwall, Mark W. / Effect of microamperage stimulation on the rate of wound healing in rats : A histological study. In: Physical Therapy. 1994 ; Vol. 74, No. 3. pp. 195-200.
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