Dose-dependent effects of DDAVP on memory in healthy young adult males: A preliminary study

Bill E. Beckwith, Robert E. Till, Claudette R. Reno, Russell E. Poland

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Although several studies have demonstrated the efficacy of the vasopressin analog DDAVP in enhancing human memory, no previous study has reported the dose-response relationship of DDAVP to memory in healthy young adults. The present study was undertaken to explore the dose-response curve for DDAVP on recall of implicational sentences. Five doses of DDAVP (0, 5, 15, 30, and 60 μg) were administered intranasally to healthy young adult male volunteers. Results demonstrated a facilitation in cued recall after treatment with the 60-μg dose and a general impairment in recall after treatment with the 15-μg dose. These effects were independent of subject's weight, vocabulary ability, and concentration of salivary cortisol.

Original languageEnglish (US)
Pages (from-to)473-476
Number of pages4
JournalPeptides
Volume11
Issue number3
DOIs
StatePublished - Jan 1 1990

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Keywords

  • Behavior
  • Cortisol
  • DDAVP
  • Memory
  • Neuropeptides
  • Vasopressin

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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