Dominance of multidrug resistant CC271 clones in macrolide-resistant streptococcus pneumoniae in Arizona

Jolene R. Bowers, Elizabeth M. Driebe, Jennifer L. Nibecker, Bette R. Wojack, Derek S. Sarovich, Ada H. Wong, Pius M. Brzoska, Nathaniel Hubert, Andrew Knadler, Lindsey M. Watson, David M Wagner, Manohar R. Furtado, Michael Saubolle, David M. Engelthaler, Paul S Keim

Research output: Contribution to journalArticle

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Abstract

Background: Rates of resistance to macrolide antibiotics in Streptococcus pneumoniae are rising around the world due to the spread of mobile genetic elements harboring mef(E) and erm(B) genes and post-vaccine clonal expansion of strains that carry them. Results: Characterization of 592 clinical isolates collected in Arizona over a 10 year period shows 23.6% are macrolide resistant. The largest portion of the macrolide-resistant population, 52%, is dual mef(E)/erm(B)-positive. All dual-positive isolates are multidrug-resistant clonal lineages of Taiwan 19F-14, mostly multilocus sequence type 320, carrying the recently described transposon Tn2010. The remainder of the macrolide resistant S. pneumoniae collection includes 31% mef(E)-positive, and 9% erm(B)-positive strains. Conclusions: The dual-positive, multidrug-resistant S. pneumoniae clones have likely expanded by switching to non-vaccine serotypes after the heptavalent pneumococcal conjugate vaccine release, and their success limits therapy options. This upsurge could have a considerable clinical impact in Arizona.

Original languageEnglish (US)
Article number12
JournalBMC Microbiology
Volume12
DOIs
StatePublished - 2012

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Macrolides
Streptococcus pneumoniae
Clone Cells
Interspersed Repetitive Sequences
Taiwan
Vaccines
Anti-Bacterial Agents
Population
Genes
Therapeutics

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

Dominance of multidrug resistant CC271 clones in macrolide-resistant streptococcus pneumoniae in Arizona. / Bowers, Jolene R.; Driebe, Elizabeth M.; Nibecker, Jennifer L.; Wojack, Bette R.; Sarovich, Derek S.; Wong, Ada H.; Brzoska, Pius M.; Hubert, Nathaniel; Knadler, Andrew; Watson, Lindsey M.; Wagner, David M; Furtado, Manohar R.; Saubolle, Michael; Engelthaler, David M.; Keim, Paul S.

In: BMC Microbiology, Vol. 12, 12, 2012.

Research output: Contribution to journalArticle

Bowers, JR, Driebe, EM, Nibecker, JL, Wojack, BR, Sarovich, DS, Wong, AH, Brzoska, PM, Hubert, N, Knadler, A, Watson, LM, Wagner, DM, Furtado, MR, Saubolle, M, Engelthaler, DM & Keim, PS 2012, 'Dominance of multidrug resistant CC271 clones in macrolide-resistant streptococcus pneumoniae in Arizona', BMC Microbiology, vol. 12, 12. https://doi.org/10.1186/1471-2180-12-12
Bowers, Jolene R. ; Driebe, Elizabeth M. ; Nibecker, Jennifer L. ; Wojack, Bette R. ; Sarovich, Derek S. ; Wong, Ada H. ; Brzoska, Pius M. ; Hubert, Nathaniel ; Knadler, Andrew ; Watson, Lindsey M. ; Wagner, David M ; Furtado, Manohar R. ; Saubolle, Michael ; Engelthaler, David M. ; Keim, Paul S. / Dominance of multidrug resistant CC271 clones in macrolide-resistant streptococcus pneumoniae in Arizona. In: BMC Microbiology. 2012 ; Vol. 12.
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