Diurnal variation in serotonin immunoreactivity in the dorsal raphe nucleus

Melissa A Birkett Greene, Katherine V. Fite

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Serotonin (5-HT) immunostained sections were analyzed using integrated optical density (IOD) measures obtained throughout the dorsal raphe nucleus (DRN) in Mongolian gerbils at selected times during a 12:12 h light:dark cycle. Substantial diurnal variation occurred in 5-HT neuronal staining density, with lowest and highest IOD values occurring at the light/dark and dark/light transitions, respectively. The injection of pargyline and tryptophan increased 5-HT immunostaining comparable to the highest level observed in control animals. Transitions between light and dark periods appear to be major environmental events that influence 5-HT levels in the DRN.

Original languageEnglish (US)
Pages (from-to)180-184
Number of pages5
JournalBrain Research
Volume1034
Issue number1-2
DOIs
StatePublished - Feb 9 2005
Externally publishedYes

Fingerprint

Serotonin
Light
Pargyline
Gerbillinae
Photoperiod
Tryptophan
Dorsal Raphe Nucleus
Staining and Labeling
Injections

Keywords

  • 5-HT immunocytochemistry
  • Mongolian gerbil
  • Optical density analysis

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Diurnal variation in serotonin immunoreactivity in the dorsal raphe nucleus. / Birkett Greene, Melissa A; Fite, Katherine V.

In: Brain Research, Vol. 1034, No. 1-2, 09.02.2005, p. 180-184.

Research output: Contribution to journalArticle

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