Diaphragmatic vasolidation elicited by pulmonary C-fiber stimulation

J. Richard Coast, Regina M. Romeo, Sharon S. Cassidy

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

This study was performed to assess the effect of pulmonary C-fiber stimulation with capsaicin on vascular resistance in the diaphragm. Nine dogs were anesthetized with pentobarbital sodium and were instrumented with right and left ventricular catheters. The left phrenic artery was isolated and perfused from an extracorporeal reservoir. Right ventricular capsaicin injections (5-20 μg/kg) caused significant decreases in phrenic perfusion pressure (-16%), systemic arterial pressure (-32%), and heart rate (-19%). Injection of identical doses of capsaicin into the left ventricle led to no significant changes in phrenic arterial perfusion pressure or systemic arterial pressure but a 10% decrease in heart rate. Bilateral cervical vagotomy eliminated the responses to both right and left ventricular injection of capsaicin, as did administration of the autonomic ganglion blocker hexamethonium bromide. The results indicate that pulmonary C-fiber stimulation reflexly vasolidates vessels in the diaphragm.

Original languageEnglish (US)
Pages (from-to)279-288
Number of pages10
JournalRespiration Physiology
Volume75
Issue number3
DOIs
StatePublished - Mar 1989
Externally publishedYes

Keywords

  • Capsaicin
  • Diaphragm
  • Dog
  • Pulmonary C-fiber

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine

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