Diaphragmatic vasolidation elicited by pulmonary C-fiber stimulation

Richard J Coast, Regina M. Romeo, Sharon S. Cassidy

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

This study was performed to assess the effect of pulmonary C-fiber stimulation with capsaicin on vascular resistance in the diaphragm. Nine dogs were anesthetized with pentobarbital sodium and were instrumented with right and left ventricular catheters. The left phrenic artery was isolated and perfused from an extracorporeal reservoir. Right ventricular capsaicin injections (5-20 μg/kg) caused significant decreases in phrenic perfusion pressure (-16%), systemic arterial pressure (-32%), and heart rate (-19%). Injection of identical doses of capsaicin into the left ventricle led to no significant changes in phrenic arterial perfusion pressure or systemic arterial pressure but a 10% decrease in heart rate. Bilateral cervical vagotomy eliminated the responses to both right and left ventricular injection of capsaicin, as did administration of the autonomic ganglion blocker hexamethonium bromide. The results indicate that pulmonary C-fiber stimulation reflexly vasolidates vessels in the diaphragm.

Original languageEnglish (US)
Pages (from-to)279-288
Number of pages10
JournalRespiration Physiology
Volume75
Issue number3
DOIs
StatePublished - 1989
Externally publishedYes

Fingerprint

Unmyelinated Nerve Fibers
Diaphragm
Capsaicin
Lung
Arterial Pressure
Injections
Perfusion
Heart Rate
Autonomic Ganglia
Hexamethonium
Vagotomy
Pentobarbital
Vascular Resistance
Heart Ventricles
Catheters
Arteries
Dogs
Pressure

Keywords

  • Capsaicin
  • Diaphragm
  • Dog
  • Pulmonary C-fiber

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine

Cite this

Diaphragmatic vasolidation elicited by pulmonary C-fiber stimulation. / Coast, Richard J; Romeo, Regina M.; Cassidy, Sharon S.

In: Respiration Physiology, Vol. 75, No. 3, 1989, p. 279-288.

Research output: Contribution to journalArticle

Coast, Richard J ; Romeo, Regina M. ; Cassidy, Sharon S. / Diaphragmatic vasolidation elicited by pulmonary C-fiber stimulation. In: Respiration Physiology. 1989 ; Vol. 75, No. 3. pp. 279-288.
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