Abstract
This study was performed to assess the effect of pulmonary C-fiber stimulation with capsaicin on vascular resistance in the diaphragm. Nine dogs were anesthetized with pentobarbital sodium and were instrumented with right and left ventricular catheters. The left phrenic artery was isolated and perfused from an extracorporeal reservoir. Right ventricular capsaicin injections (5-20 μg/kg) caused significant decreases in phrenic perfusion pressure (-16%), systemic arterial pressure (-32%), and heart rate (-19%). Injection of identical doses of capsaicin into the left ventricle led to no significant changes in phrenic arterial perfusion pressure or systemic arterial pressure but a 10% decrease in heart rate. Bilateral cervical vagotomy eliminated the responses to both right and left ventricular injection of capsaicin, as did administration of the autonomic ganglion blocker hexamethonium bromide. The results indicate that pulmonary C-fiber stimulation reflexly vasolidates vessels in the diaphragm.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 279-288 |
| Number of pages | 10 |
| Journal | Respiration Physiology |
| Volume | 75 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1989 |
| Externally published | Yes |
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Keywords
- Capsaicin
- Diaphragm
- Dog
- Pulmonary C-fiber
ASJC Scopus subject areas
- Physiology
- Pulmonary and Respiratory Medicine
Cite this
Diaphragmatic vasolidation elicited by pulmonary C-fiber stimulation. / Coast, Richard J; Romeo, Regina M.; Cassidy, Sharon S.
In: Respiration Physiology, Vol. 75, No. 3, 1989, p. 279-288.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Diaphragmatic vasolidation elicited by pulmonary C-fiber stimulation
AU - Coast, Richard J
AU - Romeo, Regina M.
AU - Cassidy, Sharon S.
PY - 1989
Y1 - 1989
N2 - This study was performed to assess the effect of pulmonary C-fiber stimulation with capsaicin on vascular resistance in the diaphragm. Nine dogs were anesthetized with pentobarbital sodium and were instrumented with right and left ventricular catheters. The left phrenic artery was isolated and perfused from an extracorporeal reservoir. Right ventricular capsaicin injections (5-20 μg/kg) caused significant decreases in phrenic perfusion pressure (-16%), systemic arterial pressure (-32%), and heart rate (-19%). Injection of identical doses of capsaicin into the left ventricle led to no significant changes in phrenic arterial perfusion pressure or systemic arterial pressure but a 10% decrease in heart rate. Bilateral cervical vagotomy eliminated the responses to both right and left ventricular injection of capsaicin, as did administration of the autonomic ganglion blocker hexamethonium bromide. The results indicate that pulmonary C-fiber stimulation reflexly vasolidates vessels in the diaphragm.
AB - This study was performed to assess the effect of pulmonary C-fiber stimulation with capsaicin on vascular resistance in the diaphragm. Nine dogs were anesthetized with pentobarbital sodium and were instrumented with right and left ventricular catheters. The left phrenic artery was isolated and perfused from an extracorporeal reservoir. Right ventricular capsaicin injections (5-20 μg/kg) caused significant decreases in phrenic perfusion pressure (-16%), systemic arterial pressure (-32%), and heart rate (-19%). Injection of identical doses of capsaicin into the left ventricle led to no significant changes in phrenic arterial perfusion pressure or systemic arterial pressure but a 10% decrease in heart rate. Bilateral cervical vagotomy eliminated the responses to both right and left ventricular injection of capsaicin, as did administration of the autonomic ganglion blocker hexamethonium bromide. The results indicate that pulmonary C-fiber stimulation reflexly vasolidates vessels in the diaphragm.
KW - Capsaicin
KW - Diaphragm
KW - Dog
KW - Pulmonary C-fiber
UR - http://www.scopus.com/inward/record.url?scp=0024563732&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024563732&partnerID=8YFLogxK
U2 - 10.1016/0034-5687(89)90038-8
DO - 10.1016/0034-5687(89)90038-8
M3 - Article
C2 - 2717817
AN - SCOPUS:0024563732
VL - 75
SP - 279
EP - 288
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
SN - 1569-9048
IS - 3
ER -