Cyclical passive stretch influences the mechanical properties of the inactive cat soleus

Roland R. Roy, David J Pierotti, Kenneth M. Baldwin, Hui Zhong, John A. Hodgson, V. Reggie Edgerton

Research output: Contribution to journalArticle

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Abstract

The effects of cyclical, passive manipulation (PM, 30 min day-1, 5 days week-1 for 6 months) mimicking the length excursions observed during stepping on the mechanical and associated biochemical properties of the inactive cat soleus muscle were determined in five cats. Inactivity was produced via spinal cord isolation (SI), i.e. complete spinal cord transections at low thoracic and high sacral levels and bilateral dorsal rhizotomy between the transection sites. Passive manipulation was administered to one leg of each SI cat. Compared with normal controls, SI resulted in ~ 70% decrease in weight, an 80% decrease in maximum tetanic tension (P0) and an ~ 100% increase in maximum rate of shortening (V(max)) and myosin adenosine triphosphatase (mATPase) activity of the soleus. The passive manipulation regime partially ameliorated these effects. When compared with the control SI soleus, the SI-PM soleus weight and maximum tetanic tension were 12 and 21% higher, respectively, and the V(max) and mATPase activity 21 and 12% (p > 0.05) lower, respectively. Thus, inactivity resulted in a smaller and faster muscle, whereas passive manipulation for only 30 min a day tended to maintain these properties closer to normal control values. The results suggest a potential therapeutic effect of short bouts of cyclical, passive manipulation on otherwise inactive skeletal muscles.

Original languageEnglish (US)
Pages (from-to)377-385
Number of pages9
JournalExperimental Physiology
Volume83
Issue number3
StatePublished - May 1998
Externally publishedYes

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Spinal Cord
Cats
Myosins
Skeletal Muscle
Rhizotomy
Weights and Measures
Therapeutic Uses
Spinal Cord Injuries
Leg
Reference Values
Thorax
Muscles

ASJC Scopus subject areas

  • Physiology

Cite this

Roy, R. R., Pierotti, D. J., Baldwin, K. M., Zhong, H., Hodgson, J. A., & Edgerton, V. R. (1998). Cyclical passive stretch influences the mechanical properties of the inactive cat soleus. Experimental Physiology, 83(3), 377-385.

Cyclical passive stretch influences the mechanical properties of the inactive cat soleus. / Roy, Roland R.; Pierotti, David J; Baldwin, Kenneth M.; Zhong, Hui; Hodgson, John A.; Edgerton, V. Reggie.

In: Experimental Physiology, Vol. 83, No. 3, 05.1998, p. 377-385.

Research output: Contribution to journalArticle

Roy, RR, Pierotti, DJ, Baldwin, KM, Zhong, H, Hodgson, JA & Edgerton, VR 1998, 'Cyclical passive stretch influences the mechanical properties of the inactive cat soleus', Experimental Physiology, vol. 83, no. 3, pp. 377-385.
Roy, Roland R. ; Pierotti, David J ; Baldwin, Kenneth M. ; Zhong, Hui ; Hodgson, John A. ; Edgerton, V. Reggie. / Cyclical passive stretch influences the mechanical properties of the inactive cat soleus. In: Experimental Physiology. 1998 ; Vol. 83, No. 3. pp. 377-385.
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