Current understanding of the human microbiome

Jack A. Gilbert, Martin J. Blaser, J. Gregory Caporaso, Janet K. Jansson, Susan V. Lynch, Rob Knight

Research output: Contribution to journalArticle

296 Scopus citations

Abstract

Our understanding of the link between the human microbiome and disease, including obesity, inflammatory bowel disease, arthritis and autism, is rapidly expanding. Improvements in the throughput and accuracy of DNA sequencing of the genomes of microbial communities that are associated with human samples, complemented by analysis of transcriptomes, proteomes, metabolomes and immunomes and by mechanistic experiments in model systems, have vastly improved our ability to understand the structure and function of the microbiome in both diseased and healthy states. However, many challenges remain. In this review, we focus on studies in humans to describe these challenges and propose strategies that leverage existing knowledge to move rapidly from correlation to causation and ultimately to translation into therapies.

Original languageEnglish (US)
Pages (from-to)392-400
Number of pages9
JournalNature Medicine
Volume24
Issue number4
DOIs
StatePublished - Apr 10 2018

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Gilbert, J. A., Blaser, M. J., Caporaso, J. G., Jansson, J. K., Lynch, S. V., & Knight, R. (2018). Current understanding of the human microbiome. Nature Medicine, 24(4), 392-400. https://doi.org/10.1038/nm.4517