Cryptic connections illuminate pathogen transmission within community networks

Joseph R. Hoyt, Kate E. Langwig, J. Paul White, Heather M. Kaarakka, Jennifer A. Redell, Allen Kurta, John E. DePue, William H. Scullon, Katy L. Parise, Jeffrey T Foster, Winifred F. Frick, A. Marm Kilpatrick

Research output: Contribution to journalLetter

2 Citations (Scopus)

Abstract

Understanding host interactions that lead to pathogen transmission is fundamental to the prediction and control of epidemics1–5. Although the majority of transmissions often occurs within social groups6–9, the contribution of connections that bridge groups and species to pathogen dynamics is poorly understood10–12. These cryptic connections—which are often indirect or infrequent—provide transmission routes between otherwise disconnected individuals and may have a key role in large-scale outbreaks that span multiple populations or species. Here we quantify the importance of cryptic connections in disease dynamics by simultaneously characterizing social networks and tracing transmission dynamics of surrogate-pathogen epidemics through eight communities of bats. We then compared these data to the invasion of the fungal pathogen that causes white-nose syndrome, a recently emerged disease that is devastating North American bat populations13–15. We found that cryptic connections increased links between individuals and between species by an order of magnitude. Individuals were connected, on average, to less than two per cent of the population through direct contact and to only six per cent through shared groups. However, tracing surrogate-pathogen dynamics showed that each individual was connected to nearly fifteen per cent of the population, and revealed widespread transmission between solitarily roosting individuals as well as extensive contacts among species. Connections estimated from surrogate-pathogen epidemics, which include cryptic connections, explained three times as much variation in the transmission of the fungus that causes white-nose syndrome as did connections based on shared groups. These findings show how cryptic connections facilitate the community-wide spread of pathogens and can lead to explosive epidemics.

Original languageEnglish (US)
Pages (from-to)710-713
Number of pages4
JournalNature
Volume563
Issue number7733
DOIs
StatePublished - Nov 29 2018

Fingerprint

Community Networks
Infectious Disease Transmission
Nose
Population
Social Support
Disease Outbreaks
Fungi

ASJC Scopus subject areas

  • General

Cite this

Hoyt, J. R., Langwig, K. E., White, J. P., Kaarakka, H. M., Redell, J. A., Kurta, A., ... Kilpatrick, A. M. (2018). Cryptic connections illuminate pathogen transmission within community networks. Nature, 563(7733), 710-713. https://doi.org/10.1038/s41586-018-0720-z

Cryptic connections illuminate pathogen transmission within community networks. / Hoyt, Joseph R.; Langwig, Kate E.; White, J. Paul; Kaarakka, Heather M.; Redell, Jennifer A.; Kurta, Allen; DePue, John E.; Scullon, William H.; Parise, Katy L.; Foster, Jeffrey T; Frick, Winifred F.; Kilpatrick, A. Marm.

In: Nature, Vol. 563, No. 7733, 29.11.2018, p. 710-713.

Research output: Contribution to journalLetter

Hoyt, JR, Langwig, KE, White, JP, Kaarakka, HM, Redell, JA, Kurta, A, DePue, JE, Scullon, WH, Parise, KL, Foster, JT, Frick, WF & Kilpatrick, AM 2018, 'Cryptic connections illuminate pathogen transmission within community networks', Nature, vol. 563, no. 7733, pp. 710-713. https://doi.org/10.1038/s41586-018-0720-z
Hoyt JR, Langwig KE, White JP, Kaarakka HM, Redell JA, Kurta A et al. Cryptic connections illuminate pathogen transmission within community networks. Nature. 2018 Nov 29;563(7733):710-713. https://doi.org/10.1038/s41586-018-0720-z
Hoyt, Joseph R. ; Langwig, Kate E. ; White, J. Paul ; Kaarakka, Heather M. ; Redell, Jennifer A. ; Kurta, Allen ; DePue, John E. ; Scullon, William H. ; Parise, Katy L. ; Foster, Jeffrey T ; Frick, Winifred F. ; Kilpatrick, A. Marm. / Cryptic connections illuminate pathogen transmission within community networks. In: Nature. 2018 ; Vol. 563, No. 7733. pp. 710-713.
@article{8f907a2a128f45fe958a32085cd9d4be,
title = "Cryptic connections illuminate pathogen transmission within community networks",
abstract = "Understanding host interactions that lead to pathogen transmission is fundamental to the prediction and control of epidemics1–5. Although the majority of transmissions often occurs within social groups6–9, the contribution of connections that bridge groups and species to pathogen dynamics is poorly understood10–12. These cryptic connections—which are often indirect or infrequent—provide transmission routes between otherwise disconnected individuals and may have a key role in large-scale outbreaks that span multiple populations or species. Here we quantify the importance of cryptic connections in disease dynamics by simultaneously characterizing social networks and tracing transmission dynamics of surrogate-pathogen epidemics through eight communities of bats. We then compared these data to the invasion of the fungal pathogen that causes white-nose syndrome, a recently emerged disease that is devastating North American bat populations13–15. We found that cryptic connections increased links between individuals and between species by an order of magnitude. Individuals were connected, on average, to less than two per cent of the population through direct contact and to only six per cent through shared groups. However, tracing surrogate-pathogen dynamics showed that each individual was connected to nearly fifteen per cent of the population, and revealed widespread transmission between solitarily roosting individuals as well as extensive contacts among species. Connections estimated from surrogate-pathogen epidemics, which include cryptic connections, explained three times as much variation in the transmission of the fungus that causes white-nose syndrome as did connections based on shared groups. These findings show how cryptic connections facilitate the community-wide spread of pathogens and can lead to explosive epidemics.",
author = "Hoyt, {Joseph R.} and Langwig, {Kate E.} and White, {J. Paul} and Kaarakka, {Heather M.} and Redell, {Jennifer A.} and Allen Kurta and DePue, {John E.} and Scullon, {William H.} and Parise, {Katy L.} and Foster, {Jeffrey T} and Frick, {Winifred F.} and Kilpatrick, {A. Marm}",
year = "2018",
month = "11",
day = "29",
doi = "10.1038/s41586-018-0720-z",
language = "English (US)",
volume = "563",
pages = "710--713",
journal = "Nature Cell Biology",
issn = "1465-7392",
publisher = "Nature Publishing Group",
number = "7733",

}

TY - JOUR

T1 - Cryptic connections illuminate pathogen transmission within community networks

AU - Hoyt, Joseph R.

AU - Langwig, Kate E.

AU - White, J. Paul

AU - Kaarakka, Heather M.

AU - Redell, Jennifer A.

AU - Kurta, Allen

AU - DePue, John E.

AU - Scullon, William H.

AU - Parise, Katy L.

AU - Foster, Jeffrey T

AU - Frick, Winifred F.

AU - Kilpatrick, A. Marm

PY - 2018/11/29

Y1 - 2018/11/29

N2 - Understanding host interactions that lead to pathogen transmission is fundamental to the prediction and control of epidemics1–5. Although the majority of transmissions often occurs within social groups6–9, the contribution of connections that bridge groups and species to pathogen dynamics is poorly understood10–12. These cryptic connections—which are often indirect or infrequent—provide transmission routes between otherwise disconnected individuals and may have a key role in large-scale outbreaks that span multiple populations or species. Here we quantify the importance of cryptic connections in disease dynamics by simultaneously characterizing social networks and tracing transmission dynamics of surrogate-pathogen epidemics through eight communities of bats. We then compared these data to the invasion of the fungal pathogen that causes white-nose syndrome, a recently emerged disease that is devastating North American bat populations13–15. We found that cryptic connections increased links between individuals and between species by an order of magnitude. Individuals were connected, on average, to less than two per cent of the population through direct contact and to only six per cent through shared groups. However, tracing surrogate-pathogen dynamics showed that each individual was connected to nearly fifteen per cent of the population, and revealed widespread transmission between solitarily roosting individuals as well as extensive contacts among species. Connections estimated from surrogate-pathogen epidemics, which include cryptic connections, explained three times as much variation in the transmission of the fungus that causes white-nose syndrome as did connections based on shared groups. These findings show how cryptic connections facilitate the community-wide spread of pathogens and can lead to explosive epidemics.

AB - Understanding host interactions that lead to pathogen transmission is fundamental to the prediction and control of epidemics1–5. Although the majority of transmissions often occurs within social groups6–9, the contribution of connections that bridge groups and species to pathogen dynamics is poorly understood10–12. These cryptic connections—which are often indirect or infrequent—provide transmission routes between otherwise disconnected individuals and may have a key role in large-scale outbreaks that span multiple populations or species. Here we quantify the importance of cryptic connections in disease dynamics by simultaneously characterizing social networks and tracing transmission dynamics of surrogate-pathogen epidemics through eight communities of bats. We then compared these data to the invasion of the fungal pathogen that causes white-nose syndrome, a recently emerged disease that is devastating North American bat populations13–15. We found that cryptic connections increased links between individuals and between species by an order of magnitude. Individuals were connected, on average, to less than two per cent of the population through direct contact and to only six per cent through shared groups. However, tracing surrogate-pathogen dynamics showed that each individual was connected to nearly fifteen per cent of the population, and revealed widespread transmission between solitarily roosting individuals as well as extensive contacts among species. Connections estimated from surrogate-pathogen epidemics, which include cryptic connections, explained three times as much variation in the transmission of the fungus that causes white-nose syndrome as did connections based on shared groups. These findings show how cryptic connections facilitate the community-wide spread of pathogens and can lead to explosive epidemics.

UR - http://www.scopus.com/inward/record.url?scp=85057570964&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85057570964&partnerID=8YFLogxK

U2 - 10.1038/s41586-018-0720-z

DO - 10.1038/s41586-018-0720-z

M3 - Letter

C2 - 30455422

AN - SCOPUS:85057570964

VL - 563

SP - 710

EP - 713

JO - Nature Cell Biology

JF - Nature Cell Biology

SN - 1465-7392

IS - 7733

ER -