Conservation of resistance-nodulation-cell division efflux pump-mediated antibiotic resistance in burkholderia cepacia complex and burkholderia pseudomallei complex species

Nawarat Somprasong, Jinhee Yi, Carina M. Hall, Jessica R. Webb, Jason W. Sahl, David M. Wagner, Paul Keim, Bart J. Currie, Herbert P. Schweizer

Research output: Contribution to journalArticlepeer-review

Abstract

Burkholderia cepacia complex (Bcc) and Burkholderia pseudomallei complex (Bpc) species include pathogens that are typically multidrug resistant. Dominant intrinsic and acquired multidrug resistance mechanisms are efflux mediated by pumps of the resistance-nodulation-cell division (RND) family. From comparative bioinformatic and, in many instances, functional studies, we infer that RND pump-based resistance mechanisms are conserved in Burkholderia. We propose to use these findings as a foundation for adoption of a uniform RND efflux pump nomenclature.

Original languageEnglish (US)
Article numbere00920-21
JournalAntimicrobial Agents and Chemotherapy
Volume65
Issue number9
DOIs
StatePublished - Sep 2021

Keywords

  • Burkholderia
  • Multidrug resistance
  • RND efflux pumps

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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