Chronic cold exposure increases skeletal muscle oxidative structure and function in Monodelphis domestica, a marsupial lacking brown adipose tissue

P. J. Schaeffer, J. J. Villarin, Stan L Lindstedt

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Monodelphis domestica (Marsupialia: Didelphidae) was used as a model animal to investigate and compare muscle adaptation to exercise training and cold exposure. The experimental treatment consisted of four groups of animals: either warm or cold acclimation temperature and with or without endurance exercise training. Maximal aerobic capacity during a running V̇o 2max test in the warm-exercised or cold-exposed (with or without exercise) groups was about 130 mL O2/kg/min, significantly higher than the warm-acclimated controls at 113.5 mL O2/kg/min. Similarly, during an acute cold challenge (V̇o2summit), maximal aerobic capacity was higher in these three experimental groups at ∼95 mL O 2/kg/min compared with 80.4 mL O2/kg/min in warm-acclimated controls. Respiratory exchange ratio was significantly lower (0.89-0.68), whereas relative heart mass (0.52%-0.73%) and whole-body muscle mitochondrial volume density (2.59 to 3.04 cm3) were significantly higher following cold exposure. Chronic cold exposure was a stronger stimulus than endurance exercise training for tissue-specific adaptations. Although chronic cold exposure and endurance exercise are distinct challenges, physiological adaptations to each overlap such that the capacities for aerobic performance in response to both cold exposure and running are increased by either or both treatments.

Original languageEnglish (US)
Pages (from-to)877-887
Number of pages11
JournalPhysiological and Biochemical Zoology
Volume76
Issue number6
DOIs
StatePublished - Nov 2003

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Monodelphis
Monodelphis domestica
Marsupialia
Brown Adipose Tissue
brown adipose tissue
Metatheria
Muscle
skeletal muscle
Skeletal Muscle
Durability
Tissue
Animals
exercise
Exercise
Running
Didelphidae
Mitochondrial Size
Physiological Adaptation
Opossums
Muscles

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Physiology
  • Physiology (medical)

Cite this

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abstract = "Monodelphis domestica (Marsupialia: Didelphidae) was used as a model animal to investigate and compare muscle adaptation to exercise training and cold exposure. The experimental treatment consisted of four groups of animals: either warm or cold acclimation temperature and with or without endurance exercise training. Maximal aerobic capacity during a running V̇o 2max test in the warm-exercised or cold-exposed (with or without exercise) groups was about 130 mL O2/kg/min, significantly higher than the warm-acclimated controls at 113.5 mL O2/kg/min. Similarly, during an acute cold challenge (V̇o2summit), maximal aerobic capacity was higher in these three experimental groups at ∼95 mL O 2/kg/min compared with 80.4 mL O2/kg/min in warm-acclimated controls. Respiratory exchange ratio was significantly lower (0.89-0.68), whereas relative heart mass (0.52{\%}-0.73{\%}) and whole-body muscle mitochondrial volume density (2.59 to 3.04 cm3) were significantly higher following cold exposure. Chronic cold exposure was a stronger stimulus than endurance exercise training for tissue-specific adaptations. Although chronic cold exposure and endurance exercise are distinct challenges, physiological adaptations to each overlap such that the capacities for aerobic performance in response to both cold exposure and running are increased by either or both treatments.",
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