Choline and Geranate Deep Eutectic Solvent as a Broad-Spectrum Antiseptic Agent for Preventive and Therapeutic Applications

Michael Zakrewsky, Amrita Banerjee, Sanjana Apte, Theresa L. Kern, Mattie R. Jones, Rico E Del Sesto, Andrew T Koppisch, David T. Fox, Samir Mitragotri

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Antiseptic agents are the primary arsenal to disinfect skin and prevent pathogens spreading within the host as well as into the surroundings; however the Food and Drug Administration published a report in 2015 requiring additional validation of nearly all current antiseptic agents before their continued use can be allowed. This vulnerable position calls for urgent identification of novel antiseptic agents. Recently, the ability of a deep eutectic, Choline And Geranate (CAGE), to treat biofilms of Pseudomonas aeruginosa and Salmonella enterica was demonstrated. Here it is reported that CAGE exhibits broad-spectrum antimicrobial activity against a number of drug-resistant bacteria, fungi, and viruses including clinical isolates of Mycobacterium tuberculosis, Staphylococcus aureus, and Candida albicans as well as laboratory strains of Herpes Simplex Virus. Studies in human keratinocytes and mice show that CAGE affords negligible local or systemic toxicity, and an ≈180–14 000-fold improved efficacy/toxicity ratio over currently used antiseptic agents. Further, CAGE penetrates deep into the dermis and treats pathogens located in deep skin layers as confirmed by the ability of CAGE in vivo to treat Propionibacterium acnes infection. In combination, the results clearly demonstrate CAGE holds promise as a transformative platform antiseptic agent for preventive as well as therapeutic applications.

Original languageEnglish (US)
Pages (from-to)1282-1289
Number of pages8
JournalAdvanced healthcare materials
Volume5
Issue number11
DOIs
StatePublished - Jun 8 2016

Keywords

  • antimicrobial resistance
  • antiseptics
  • beacterial infections
  • drug delivery
  • infection prevention

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Pharmaceutical Science

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    Zakrewsky, M., Banerjee, A., Apte, S., Kern, T. L., Jones, M. R., Sesto, R. E. D., Koppisch, A. T., Fox, D. T., & Mitragotri, S. (2016). Choline and Geranate Deep Eutectic Solvent as a Broad-Spectrum Antiseptic Agent for Preventive and Therapeutic Applications. Advanced healthcare materials, 5(11), 1282-1289. https://doi.org/10.1002/adhm.201600086