Bacillus anthracis diversity in Kruger National Park

K. L. Smith, V. DeVos, H. Bryden, L. B. Price, M. E. Hugh-Jones, Paul S Keim

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

The Kruger National Park (KNP), South Africa, has a recorded history of periodic anthrax epidemics causing widespread disease among wild animals. Bacillus anthracis is the causative agent of anthrax, a disease primarily affecting ungulate herbivores. Worldwide there is little diversity among B. anthracis isolates, but examination of variable-number tandem repeat (VNTR) loci has identified six major clones, with the most dissimilar types split into the A and B branches. Both the A and B types are found in southern Africa, giving this region the greatest genetic diversity of B. anthracis worldwide. Consequently, southern Africa has been hypothesized to be the geographic origin of B. anthracis. In this study, we identify the genotypic types of 98 KNP B. anthracis isolates using multiple-locus VNTR analysis. Two major types are evident, the A branch and the B branch. The spatial and temporal distribution of the different genotypes indicates that anthrax epidemic foci are independent, though correlated through environmental cues. Kruger B isolates were found on significantly higher-calcium and higher-pH soils than were Kruger type A. This relationship between genotype and soil chemistry may be due to adaptive differences among divergent anthrax strains. While this association may be simply fortuitous, adaptation of A types to diverse environmental conditions is consistent with their greater geographic dispersal and genetic dissimilarity.

Original languageEnglish (US)
Pages (from-to)3780-3784
Number of pages5
JournalJournal of Clinical Microbiology
Volume38
Issue number10
StatePublished - 2000

Fingerprint

Bacillus anthracis
Anthrax
Southern Africa
Minisatellite Repeats
Soil
Genotype
Herbivory
Wild Animals
South Africa
Cues
Clone Cells
Recreational Parks
Calcium

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

Smith, K. L., DeVos, V., Bryden, H., Price, L. B., Hugh-Jones, M. E., & Keim, P. S. (2000). Bacillus anthracis diversity in Kruger National Park. Journal of Clinical Microbiology, 38(10), 3780-3784.

Bacillus anthracis diversity in Kruger National Park. / Smith, K. L.; DeVos, V.; Bryden, H.; Price, L. B.; Hugh-Jones, M. E.; Keim, Paul S.

In: Journal of Clinical Microbiology, Vol. 38, No. 10, 2000, p. 3780-3784.

Research output: Contribution to journalArticle

Smith, KL, DeVos, V, Bryden, H, Price, LB, Hugh-Jones, ME & Keim, PS 2000, 'Bacillus anthracis diversity in Kruger National Park', Journal of Clinical Microbiology, vol. 38, no. 10, pp. 3780-3784.
Smith KL, DeVos V, Bryden H, Price LB, Hugh-Jones ME, Keim PS. Bacillus anthracis diversity in Kruger National Park. Journal of Clinical Microbiology. 2000;38(10):3780-3784.
Smith, K. L. ; DeVos, V. ; Bryden, H. ; Price, L. B. ; Hugh-Jones, M. E. ; Keim, Paul S. / Bacillus anthracis diversity in Kruger National Park. In: Journal of Clinical Microbiology. 2000 ; Vol. 38, No. 10. pp. 3780-3784.
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