Anaphylactoid response to Optison® and its effects on pulmonary function in two dogs

Yoshiki Yamaya, Kyuichi Niizeki, Jeannie Kim, Pauline Entin, Harrieth Wagner, Peter D. Wagner

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Two of 26 anesthetized dogs given the cardiac echo-enhancing agent Optison® showed anaphylactoid responses (AR) related to the human albumin component of this agent. The episodes of AR were self-limited, and could be reproduced by human albumin injection alone. Gas exchange was maintained by mechanical ventilation and 5 cm H2O PEEP, and dispersion of ventilation remained normal during AR despite severe hypotension. We suggest that: (1) pre-screening by measuring blood pressure response to intravenous injection of small doses of Optison®, and (2) availability of access to the airway in addition to emergency agents may be prudent preventive measures when Optison® is used in animals to enhance echocardiographic imaging.

Original languageEnglish (US)
Pages (from-to)1429-1432
Number of pages4
JournalJournal of Veterinary Medical Science
Volume66
Issue number11
DOIs
StatePublished - Nov 2004
Externally publishedYes

Fingerprint

lung function
albumins
Dogs
Lung
dogs
Albumins
hypotension
intravenous injection
blood pressure
gas exchange
image analysis
injection
screening
Artificial Respiration
Intravenous Injections
Hypotension
Ventilation
Emergencies
dosage
Gases

Keywords

  • Gas exchange
  • Human albumin
  • Hypotension

ASJC Scopus subject areas

  • veterinary(all)
  • Marketing

Cite this

Anaphylactoid response to Optison® and its effects on pulmonary function in two dogs. / Yamaya, Yoshiki; Niizeki, Kyuichi; Kim, Jeannie; Entin, Pauline; Wagner, Harrieth; Wagner, Peter D.

In: Journal of Veterinary Medical Science, Vol. 66, No. 11, 11.2004, p. 1429-1432.

Research output: Contribution to journalArticle

Yamaya, Yoshiki ; Niizeki, Kyuichi ; Kim, Jeannie ; Entin, Pauline ; Wagner, Harrieth ; Wagner, Peter D. / Anaphylactoid response to Optison® and its effects on pulmonary function in two dogs. In: Journal of Veterinary Medical Science. 2004 ; Vol. 66, No. 11. pp. 1429-1432.
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