Alterations in electrocardiographic parameters induced by acute infection with Pseudomonas aeruginosa wild-type and mucoid strains in mice

M. S. Lo Presti, J. G. Leid, E. Grondona, Fernando P Monroy, C. M. Bigliani, O. Pessah, A. A. Ponce

Research output: Contribution to journalArticle

Abstract

Pseudomonas aeruginosa (PA) is a pathogen in patients with cystic fibrosis (CF) and burn wound infections. Few studies have investigated the role of PA in electrocardiogram parameters (ECGs) with acute infection. We hypothesized that PA induces adverse ECGs effects in mice. After inoculation with wild-type strain PA14, the mucoid CF isolate FRD1 (mucA22+), which produces extensive alginate and has a natural mucoid phenotype, and the PA14algD- strain that cannot produce alginate, were evaluated by computerized electrocardiographic. ECG conduction changes were present in the P wave, the R-R interval and heart frequency in all PA strains and the PR interval were significantly prolonged with PA infection with PA14 algD- and FRD1, compared to the control (P < 0.05), indicating slowed atrial and atrial-ventricular conduction. We conclude that PA produces bradycardia and demonstrated dramatic decreases in other ECGs associated with exposure to wild-type and mutant from PA. Furthermore, the mechanisms by which PA affects cardiac conduction remain uncertain.

Original languageEnglish (US)
Pages (from-to)381-385
Number of pages5
JournalWorld Journal of Microbiology and Biotechnology
Volume26
Issue number2
DOIs
StatePublished - Feb 2010

    Fingerprint

Keywords

  • Cystic fibrosis
  • ECG
  • Mice
  • Pseudomonas aeruginosa
  • Sepsis

ASJC Scopus subject areas

  • Biotechnology
  • Physiology
  • Applied Microbiology and Biotechnology

Cite this