All in the family: Evolutionary and functional relationships among death receptors

J. T. Bridgham, Jason A Wilder, H. Hollocher, A. L. Johnson

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Over the last decade, significant progress has been made towards identifying the signaling pathways within mammalian cells that lead to apoptosis mediated by death receptors. The simultaneous expression of more than one death receptor in many, if not all, cell types suggests that functional innovation has driven the divergence of these receptors and their cognate ligands. To better understand the physiological divergence of the death receptors, a phylogenetic analysis of vertebrate death receptors was conducted based upon amino-acid sequences encoding the death domain regions of currently known and newly identified members of the family. Evidence is presented to indicate an ancient radiation of death receptors that predates the emergence of vertebrates, as well as ongoing divergence of additional receptors both within several receptor lineages as well as modern taxonomic lineages. We speculate that divergence among death receptors has led to their functional specialization. For instance, some receptors appear to be primarily involved in mediating the immune response, while others play critical roles during development and tissue differentiation. The following represents an evolutionary approach towards an understanding of the complex relationship among death receptors and their proposed physiological functions in vertebrate species.

Original languageEnglish (US)
Pages (from-to)19-25
Number of pages7
JournalCell Death and Differentiation
Volume10
Issue number1
DOIs
StatePublished - Jan 1 2003
Externally publishedYes

Fingerprint

Death Domain Receptors
Vertebrates
Prednisolone
Amino Acid Sequence
Radiation
Apoptosis
Ligands

Keywords

  • Apoptosis
  • Death receptors
  • Phylogeny
  • Vertebrates

ASJC Scopus subject areas

  • Cell Biology

Cite this

All in the family : Evolutionary and functional relationships among death receptors. / Bridgham, J. T.; Wilder, Jason A; Hollocher, H.; Johnson, A. L.

In: Cell Death and Differentiation, Vol. 10, No. 1, 01.01.2003, p. 19-25.

Research output: Contribution to journalArticle

Bridgham, J. T. ; Wilder, Jason A ; Hollocher, H. ; Johnson, A. L. / All in the family : Evolutionary and functional relationships among death receptors. In: Cell Death and Differentiation. 2003 ; Vol. 10, No. 1. pp. 19-25.
@article{0ae7ffdf554e480c8b875d910503ad7c,
title = "All in the family: Evolutionary and functional relationships among death receptors",
abstract = "Over the last decade, significant progress has been made towards identifying the signaling pathways within mammalian cells that lead to apoptosis mediated by death receptors. The simultaneous expression of more than one death receptor in many, if not all, cell types suggests that functional innovation has driven the divergence of these receptors and their cognate ligands. To better understand the physiological divergence of the death receptors, a phylogenetic analysis of vertebrate death receptors was conducted based upon amino-acid sequences encoding the death domain regions of currently known and newly identified members of the family. Evidence is presented to indicate an ancient radiation of death receptors that predates the emergence of vertebrates, as well as ongoing divergence of additional receptors both within several receptor lineages as well as modern taxonomic lineages. We speculate that divergence among death receptors has led to their functional specialization. For instance, some receptors appear to be primarily involved in mediating the immune response, while others play critical roles during development and tissue differentiation. The following represents an evolutionary approach towards an understanding of the complex relationship among death receptors and their proposed physiological functions in vertebrate species.",
keywords = "Apoptosis, Death receptors, Phylogeny, Vertebrates",
author = "Bridgham, {J. T.} and Wilder, {Jason A} and H. Hollocher and Johnson, {A. L.}",
year = "2003",
month = "1",
day = "1",
doi = "10.1038/sj.cdd.4401174",
language = "English (US)",
volume = "10",
pages = "19--25",
journal = "Cell Death and Differentiation",
issn = "1350-9047",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - All in the family

T2 - Evolutionary and functional relationships among death receptors

AU - Bridgham, J. T.

AU - Wilder, Jason A

AU - Hollocher, H.

AU - Johnson, A. L.

PY - 2003/1/1

Y1 - 2003/1/1

N2 - Over the last decade, significant progress has been made towards identifying the signaling pathways within mammalian cells that lead to apoptosis mediated by death receptors. The simultaneous expression of more than one death receptor in many, if not all, cell types suggests that functional innovation has driven the divergence of these receptors and their cognate ligands. To better understand the physiological divergence of the death receptors, a phylogenetic analysis of vertebrate death receptors was conducted based upon amino-acid sequences encoding the death domain regions of currently known and newly identified members of the family. Evidence is presented to indicate an ancient radiation of death receptors that predates the emergence of vertebrates, as well as ongoing divergence of additional receptors both within several receptor lineages as well as modern taxonomic lineages. We speculate that divergence among death receptors has led to their functional specialization. For instance, some receptors appear to be primarily involved in mediating the immune response, while others play critical roles during development and tissue differentiation. The following represents an evolutionary approach towards an understanding of the complex relationship among death receptors and their proposed physiological functions in vertebrate species.

AB - Over the last decade, significant progress has been made towards identifying the signaling pathways within mammalian cells that lead to apoptosis mediated by death receptors. The simultaneous expression of more than one death receptor in many, if not all, cell types suggests that functional innovation has driven the divergence of these receptors and their cognate ligands. To better understand the physiological divergence of the death receptors, a phylogenetic analysis of vertebrate death receptors was conducted based upon amino-acid sequences encoding the death domain regions of currently known and newly identified members of the family. Evidence is presented to indicate an ancient radiation of death receptors that predates the emergence of vertebrates, as well as ongoing divergence of additional receptors both within several receptor lineages as well as modern taxonomic lineages. We speculate that divergence among death receptors has led to their functional specialization. For instance, some receptors appear to be primarily involved in mediating the immune response, while others play critical roles during development and tissue differentiation. The following represents an evolutionary approach towards an understanding of the complex relationship among death receptors and their proposed physiological functions in vertebrate species.

KW - Apoptosis

KW - Death receptors

KW - Phylogeny

KW - Vertebrates

UR - http://www.scopus.com/inward/record.url?scp=0242669384&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0242669384&partnerID=8YFLogxK

U2 - 10.1038/sj.cdd.4401174

DO - 10.1038/sj.cdd.4401174

M3 - Article

C2 - 12655292

AN - SCOPUS:0242669384

VL - 10

SP - 19

EP - 25

JO - Cell Death and Differentiation

JF - Cell Death and Differentiation

SN - 1350-9047

IS - 1

ER -