Aging

Compensation or maturation?

Cheryl J. Aine, Christopher C Woodruff, Janice E. Knoefel, John C. Adair, David Hudson, Clifford Qualls, Jeremy Bockholt, Elaine Best, Sanja Kovacevic, Wayne Cobb, Denise Padilla, Blaine Hart, Julia M. Stephen

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Neuroimaging studies of healthy aging often reveal differences in neural activation patterns between young and elderly groups for episodic memory tasks, even though there are no differences in behavioral performance. One explanation typically offered is that the elderly compensate for their memory deficiencies through the recruitment of additional prefrontal regions. The present study of healthy aging compared magnetoencephalographic (MEG) timecourses localized to specific cortical regions in two groups of subjects (20-29 years and ≥65 years) during a visual delayed-match-to-sample (DMS) task. MR morphometrics and neuropsychological test results were also examined with the hope of providing insight into the nature of the age-related differences. The behavioral results indicated no differences in performance between young and elderly groups. Although there was a main effect of age on the latency of the initial peak in primary/secondary visual cortex, these longer latencies were not correlated with the performance of elderly on the DMS task. The lateral occipital gyrus (LOG) revealed qualitatively different patterns of activity for the two age groups corroborated by neuropsychological test results. Morphometric results for the young versus elderly groups revealed less white (WM) and gray matter (GM) volumes in the frontal lobes of the elderly. When a group of middle-aged subjects (33-43 years) was included in the morphometric analyses, the middle-aged subjects revealed statistically greater WM volumes in frontal and parietal cortex suggesting immature WM tracts in the young. Perhaps our elderly utilized a different strategy compared to the young due to the different brain maturation levels of these groups.

Original languageEnglish (US)
Pages (from-to)1891-1904
Number of pages14
JournalNeuroImage
Volume32
Issue number4
DOIs
StatePublished - Oct 1 2006
Externally publishedYes

Fingerprint

Neuropsychological Tests
Frontal Lobe
Occipital Lobe
Parietal Lobe
Episodic Memory
Visual Cortex
Neuroimaging
Age Groups
Brain
White Matter
Gray Matter

Keywords

  • Aging
  • Brain mapping
  • Delayed-match-to-sample
  • Gray and white matter volumes
  • MEG
  • Morphometrics
  • Recognition memory
  • Working memory

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Aine, C. J., Woodruff, C. C., Knoefel, J. E., Adair, J. C., Hudson, D., Qualls, C., ... Stephen, J. M. (2006). Aging: Compensation or maturation? NeuroImage, 32(4), 1891-1904. https://doi.org/10.1016/j.neuroimage.2006.05.005

Aging : Compensation or maturation? / Aine, Cheryl J.; Woodruff, Christopher C; Knoefel, Janice E.; Adair, John C.; Hudson, David; Qualls, Clifford; Bockholt, Jeremy; Best, Elaine; Kovacevic, Sanja; Cobb, Wayne; Padilla, Denise; Hart, Blaine; Stephen, Julia M.

In: NeuroImage, Vol. 32, No. 4, 01.10.2006, p. 1891-1904.

Research output: Contribution to journalArticle

Aine, CJ, Woodruff, CC, Knoefel, JE, Adair, JC, Hudson, D, Qualls, C, Bockholt, J, Best, E, Kovacevic, S, Cobb, W, Padilla, D, Hart, B & Stephen, JM 2006, 'Aging: Compensation or maturation?', NeuroImage, vol. 32, no. 4, pp. 1891-1904. https://doi.org/10.1016/j.neuroimage.2006.05.005
Aine CJ, Woodruff CC, Knoefel JE, Adair JC, Hudson D, Qualls C et al. Aging: Compensation or maturation? NeuroImage. 2006 Oct 1;32(4):1891-1904. https://doi.org/10.1016/j.neuroimage.2006.05.005
Aine, Cheryl J. ; Woodruff, Christopher C ; Knoefel, Janice E. ; Adair, John C. ; Hudson, David ; Qualls, Clifford ; Bockholt, Jeremy ; Best, Elaine ; Kovacevic, Sanja ; Cobb, Wayne ; Padilla, Denise ; Hart, Blaine ; Stephen, Julia M. / Aging : Compensation or maturation?. In: NeuroImage. 2006 ; Vol. 32, No. 4. pp. 1891-1904.
@article{25bc1376fa654ebabaebf2184c455b6f,
title = "Aging: Compensation or maturation?",
abstract = "Neuroimaging studies of healthy aging often reveal differences in neural activation patterns between young and elderly groups for episodic memory tasks, even though there are no differences in behavioral performance. One explanation typically offered is that the elderly compensate for their memory deficiencies through the recruitment of additional prefrontal regions. The present study of healthy aging compared magnetoencephalographic (MEG) timecourses localized to specific cortical regions in two groups of subjects (20-29 years and ≥65 years) during a visual delayed-match-to-sample (DMS) task. MR morphometrics and neuropsychological test results were also examined with the hope of providing insight into the nature of the age-related differences. The behavioral results indicated no differences in performance between young and elderly groups. Although there was a main effect of age on the latency of the initial peak in primary/secondary visual cortex, these longer latencies were not correlated with the performance of elderly on the DMS task. The lateral occipital gyrus (LOG) revealed qualitatively different patterns of activity for the two age groups corroborated by neuropsychological test results. Morphometric results for the young versus elderly groups revealed less white (WM) and gray matter (GM) volumes in the frontal lobes of the elderly. When a group of middle-aged subjects (33-43 years) was included in the morphometric analyses, the middle-aged subjects revealed statistically greater WM volumes in frontal and parietal cortex suggesting immature WM tracts in the young. Perhaps our elderly utilized a different strategy compared to the young due to the different brain maturation levels of these groups.",
keywords = "Aging, Brain mapping, Delayed-match-to-sample, Gray and white matter volumes, MEG, Morphometrics, Recognition memory, Working memory",
author = "Aine, {Cheryl J.} and Woodruff, {Christopher C} and Knoefel, {Janice E.} and Adair, {John C.} and David Hudson and Clifford Qualls and Jeremy Bockholt and Elaine Best and Sanja Kovacevic and Wayne Cobb and Denise Padilla and Blaine Hart and Stephen, {Julia M.}",
year = "2006",
month = "10",
day = "1",
doi = "10.1016/j.neuroimage.2006.05.005",
language = "English (US)",
volume = "32",
pages = "1891--1904",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Academic Press Inc.",
number = "4",

}

TY - JOUR

T1 - Aging

T2 - Compensation or maturation?

AU - Aine, Cheryl J.

AU - Woodruff, Christopher C

AU - Knoefel, Janice E.

AU - Adair, John C.

AU - Hudson, David

AU - Qualls, Clifford

AU - Bockholt, Jeremy

AU - Best, Elaine

AU - Kovacevic, Sanja

AU - Cobb, Wayne

AU - Padilla, Denise

AU - Hart, Blaine

AU - Stephen, Julia M.

PY - 2006/10/1

Y1 - 2006/10/1

N2 - Neuroimaging studies of healthy aging often reveal differences in neural activation patterns between young and elderly groups for episodic memory tasks, even though there are no differences in behavioral performance. One explanation typically offered is that the elderly compensate for their memory deficiencies through the recruitment of additional prefrontal regions. The present study of healthy aging compared magnetoencephalographic (MEG) timecourses localized to specific cortical regions in two groups of subjects (20-29 years and ≥65 years) during a visual delayed-match-to-sample (DMS) task. MR morphometrics and neuropsychological test results were also examined with the hope of providing insight into the nature of the age-related differences. The behavioral results indicated no differences in performance between young and elderly groups. Although there was a main effect of age on the latency of the initial peak in primary/secondary visual cortex, these longer latencies were not correlated with the performance of elderly on the DMS task. The lateral occipital gyrus (LOG) revealed qualitatively different patterns of activity for the two age groups corroborated by neuropsychological test results. Morphometric results for the young versus elderly groups revealed less white (WM) and gray matter (GM) volumes in the frontal lobes of the elderly. When a group of middle-aged subjects (33-43 years) was included in the morphometric analyses, the middle-aged subjects revealed statistically greater WM volumes in frontal and parietal cortex suggesting immature WM tracts in the young. Perhaps our elderly utilized a different strategy compared to the young due to the different brain maturation levels of these groups.

AB - Neuroimaging studies of healthy aging often reveal differences in neural activation patterns between young and elderly groups for episodic memory tasks, even though there are no differences in behavioral performance. One explanation typically offered is that the elderly compensate for their memory deficiencies through the recruitment of additional prefrontal regions. The present study of healthy aging compared magnetoencephalographic (MEG) timecourses localized to specific cortical regions in two groups of subjects (20-29 years and ≥65 years) during a visual delayed-match-to-sample (DMS) task. MR morphometrics and neuropsychological test results were also examined with the hope of providing insight into the nature of the age-related differences. The behavioral results indicated no differences in performance between young and elderly groups. Although there was a main effect of age on the latency of the initial peak in primary/secondary visual cortex, these longer latencies were not correlated with the performance of elderly on the DMS task. The lateral occipital gyrus (LOG) revealed qualitatively different patterns of activity for the two age groups corroborated by neuropsychological test results. Morphometric results for the young versus elderly groups revealed less white (WM) and gray matter (GM) volumes in the frontal lobes of the elderly. When a group of middle-aged subjects (33-43 years) was included in the morphometric analyses, the middle-aged subjects revealed statistically greater WM volumes in frontal and parietal cortex suggesting immature WM tracts in the young. Perhaps our elderly utilized a different strategy compared to the young due to the different brain maturation levels of these groups.

KW - Aging

KW - Brain mapping

KW - Delayed-match-to-sample

KW - Gray and white matter volumes

KW - MEG

KW - Morphometrics

KW - Recognition memory

KW - Working memory

UR - http://www.scopus.com/inward/record.url?scp=33748302792&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748302792&partnerID=8YFLogxK

U2 - 10.1016/j.neuroimage.2006.05.005

DO - 10.1016/j.neuroimage.2006.05.005

M3 - Article

VL - 32

SP - 1891

EP - 1904

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

IS - 4

ER -