Acute exercise increases resistance to oxidative stress in young but not older adults

Trevor C. Nordin, Aaron J. Done, Tinna Traustadottir

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A single bout of acute exercise increases oxidative stress and stimulates a transient increase in antioxidant enzymes. We asked whether this response would induce protection from a subsequent oxidative challenge, different from that of exercise, and whether the effects were affected by aging. We compared young (20 ± 1 years, n = 8) and older (58 ± 6 years, n = 9) healthy men and women. Resistance to oxidative stress was measured by the F2-isoprostane response to forearm ischemia/reperfusion (I/R) trial. Each participant underwent the I/R trial twice, in random order; once after performing 45 min of cycling on the preceding day (IRX) and a control trial without any physical activity (IRC). Baseline F2-isoprostane levels were significantly lower at IRX compared to IRC (P < 0.05) and not different between groups. F2-isoprostane response to IRX was significantly lower compared to IRC in young (P < 0.05) but not different in the older group. Superoxide dismutase activity in response to acute exercise was significantly higher in young compared to older adults (P < 0.05). These data suggest that signal transduction of acute exercise may be impaired with aging. Repeated bouts of transient reactive oxygen species production as seen with regular exercise may be needed to increase resistance to oxidative stress in older individuals.

Original languageEnglish (US)
Pages (from-to)9727
Number of pages1
JournalAge
Volume36
Issue number6
DOIs
StatePublished - 2014

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Oxidative Stress
F2-Isoprostanes
Exercise
Reperfusion
Ischemia
Forearm
Superoxide Dismutase
Reactive Oxygen Species
Signal Transduction
Antioxidants
Enzymes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Acute exercise increases resistance to oxidative stress in young but not older adults. / Nordin, Trevor C.; Done, Aaron J.; Traustadottir, Tinna.

In: Age, Vol. 36, No. 6, 2014, p. 9727.

Research output: Contribution to journalArticle

Nordin, Trevor C. ; Done, Aaron J. ; Traustadottir, Tinna. / Acute exercise increases resistance to oxidative stress in young but not older adults. In: Age. 2014 ; Vol. 36, No. 6. pp. 9727.
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