A single introduction of Yersinia pestis to Brazil during the 3rd plague pandemic

Amy J. Vogler, Jason W. Sahl, Nilma C. Leal, Marise Sobreira, Charles H.D. Williamson, Molly C. Bollig, Dawn N. Birdsell, Andrew Rivera, Brian Thompson, Roxanne Nottingham, Antonio M. Rezende, Paul S Keim, Alzira M.P. Almeida, David M Wagner

Research output: Contribution to journalArticle

Abstract

Yersinia pestis was introduced to Brazil during the third plague pandemic and currently exists in several recognized foci. There is currently limited available phylogeographic data regarding Y. pestis in Brazil. We generated whole genome sequences for 411 Y. pestis strains from six Brazilian foci to investigate the phylogeography of Y. pestis in Brazil; these strains were isolated from 1966 to 1997. All 411 strains were assigned to a single monophyletic clade within the 1.ORI population, indicating a single Y. pestis introduction was responsible for the successful establishment of endemic foci in Brazil. There was a moderate level of genomic diversity but little population structure among the 411 Brazilian Y. pestis strains, consistent with a radial expansion wherein Y. pestis spread rapidly from the coast to the interior of Brazil and became ecologically established. Overall, there were no strong spatial or temporal patterns among the Brazilian strains. However, strains from the same focus tended to be more closely related and strains isolated from foci closer to the coast tended to fall in more basal positions in the whole genome phylogeny than strains from more interior foci. Overall, the patterns observed in Brazil are similar to other locations affected during the 3rd plague pandemic such as in North America and Madagascar.

Original languageEnglish (US)
Article numbere0209478
JournalPLoS One
Volume14
Issue number1
DOIs
StatePublished - Jan 1 2019

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Yersinia pestis
Plague
plague
Pandemics
pandemic
Brazil
Coastal zones
Genes
Genome
Phylogeography
Madagascar
coasts
Phylogeny
genome
North America
Population
phylogeography
population structure
genomics
phylogeny

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Vogler, A. J., Sahl, J. W., Leal, N. C., Sobreira, M., Williamson, C. H. D., Bollig, M. C., ... Wagner, D. M. (2019). A single introduction of Yersinia pestis to Brazil during the 3rd plague pandemic. PLoS One, 14(1), [e0209478]. https://doi.org/10.1371/journal.pone.0209478

A single introduction of Yersinia pestis to Brazil during the 3rd plague pandemic. / Vogler, Amy J.; Sahl, Jason W.; Leal, Nilma C.; Sobreira, Marise; Williamson, Charles H.D.; Bollig, Molly C.; Birdsell, Dawn N.; Rivera, Andrew; Thompson, Brian; Nottingham, Roxanne; Rezende, Antonio M.; Keim, Paul S; Almeida, Alzira M.P.; Wagner, David M.

In: PLoS One, Vol. 14, No. 1, e0209478, 01.01.2019.

Research output: Contribution to journalArticle

Vogler, AJ, Sahl, JW, Leal, NC, Sobreira, M, Williamson, CHD, Bollig, MC, Birdsell, DN, Rivera, A, Thompson, B, Nottingham, R, Rezende, AM, Keim, PS, Almeida, AMP & Wagner, DM 2019, 'A single introduction of Yersinia pestis to Brazil during the 3rd plague pandemic', PLoS One, vol. 14, no. 1, e0209478. https://doi.org/10.1371/journal.pone.0209478
Vogler AJ, Sahl JW, Leal NC, Sobreira M, Williamson CHD, Bollig MC et al. A single introduction of Yersinia pestis to Brazil during the 3rd plague pandemic. PLoS One. 2019 Jan 1;14(1). e0209478. https://doi.org/10.1371/journal.pone.0209478
Vogler, Amy J. ; Sahl, Jason W. ; Leal, Nilma C. ; Sobreira, Marise ; Williamson, Charles H.D. ; Bollig, Molly C. ; Birdsell, Dawn N. ; Rivera, Andrew ; Thompson, Brian ; Nottingham, Roxanne ; Rezende, Antonio M. ; Keim, Paul S ; Almeida, Alzira M.P. ; Wagner, David M. / A single introduction of Yersinia pestis to Brazil during the 3rd plague pandemic. In: PLoS One. 2019 ; Vol. 14, No. 1.
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