A prediction of chromium(III) accumulation in humans from chromium dietary supplements

Diane M Stearns, Joseph J. Belbruno, Karen E. Wetterhahn

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

It has been proposed that 90% of American's diets are deficient in the trace essential mineral chromium. Several chromium(III) dietary supplements are currently available to alleviate this deficiency. We show here that the same pharmacokinetic models that have been used to quantitate absorption of chromium(III) in humans predict that ingested chromium(III) will accumulate and be retained in human tissues for extended periods. Calculations were carried out with the popular supplement chromium picolinate as an example, but may be applied to any chromium(III) complex. Results from these calculations were compared to clinical data obtained from chromium(III) absorption/retention studies in humans. The models predict that chromium(III) can accumulate in human tissues to reach the levels at which DNA damage has been observed in animals and in vitro. The use of chromium supplements for extended periods or in excess dosages should be reevaluated in terms of these established models because the possible long-term biological effects of chromium accumulation in humans are poorly understood.

Original languageEnglish (US)
Pages (from-to)1650-1657
Number of pages8
JournalFASEB Journal
Volume9
Issue number15
StatePublished - 1995
Externally publishedYes

Fingerprint

Dietary supplements
Chromium
Dietary Supplements
chromium
dietary supplements
prediction
Tissue
Pharmacokinetics
Trace Elements
Nutrition
DNA Damage
Minerals
DNA damage
pharmacokinetics
Animals

Keywords

  • absorption
  • chromium
  • picolinic acid
  • supplementation
  • toxicity

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

A prediction of chromium(III) accumulation in humans from chromium dietary supplements. / Stearns, Diane M; Belbruno, Joseph J.; Wetterhahn, Karen E.

In: FASEB Journal, Vol. 9, No. 15, 1995, p. 1650-1657.

Research output: Contribution to journalArticle

Stearns, DM, Belbruno, JJ & Wetterhahn, KE 1995, 'A prediction of chromium(III) accumulation in humans from chromium dietary supplements', FASEB Journal, vol. 9, no. 15, pp. 1650-1657.
Stearns, Diane M ; Belbruno, Joseph J. ; Wetterhahn, Karen E. / A prediction of chromium(III) accumulation in humans from chromium dietary supplements. In: FASEB Journal. 1995 ; Vol. 9, No. 15. pp. 1650-1657.
@article{b38ac4c5f6b74797819992470a07f768,
title = "A prediction of chromium(III) accumulation in humans from chromium dietary supplements",
abstract = "It has been proposed that 90{\%} of American's diets are deficient in the trace essential mineral chromium. Several chromium(III) dietary supplements are currently available to alleviate this deficiency. We show here that the same pharmacokinetic models that have been used to quantitate absorption of chromium(III) in humans predict that ingested chromium(III) will accumulate and be retained in human tissues for extended periods. Calculations were carried out with the popular supplement chromium picolinate as an example, but may be applied to any chromium(III) complex. Results from these calculations were compared to clinical data obtained from chromium(III) absorption/retention studies in humans. The models predict that chromium(III) can accumulate in human tissues to reach the levels at which DNA damage has been observed in animals and in vitro. The use of chromium supplements for extended periods or in excess dosages should be reevaluated in terms of these established models because the possible long-term biological effects of chromium accumulation in humans are poorly understood.",
keywords = "absorption, chromium, picolinic acid, supplementation, toxicity",
author = "Stearns, {Diane M} and Belbruno, {Joseph J.} and Wetterhahn, {Karen E.}",
year = "1995",
language = "English (US)",
volume = "9",
pages = "1650--1657",
journal = "FASEB Journal",
issn = "0892-6638",
publisher = "FASEB",
number = "15",

}

TY - JOUR

T1 - A prediction of chromium(III) accumulation in humans from chromium dietary supplements

AU - Stearns, Diane M

AU - Belbruno, Joseph J.

AU - Wetterhahn, Karen E.

PY - 1995

Y1 - 1995

N2 - It has been proposed that 90% of American's diets are deficient in the trace essential mineral chromium. Several chromium(III) dietary supplements are currently available to alleviate this deficiency. We show here that the same pharmacokinetic models that have been used to quantitate absorption of chromium(III) in humans predict that ingested chromium(III) will accumulate and be retained in human tissues for extended periods. Calculations were carried out with the popular supplement chromium picolinate as an example, but may be applied to any chromium(III) complex. Results from these calculations were compared to clinical data obtained from chromium(III) absorption/retention studies in humans. The models predict that chromium(III) can accumulate in human tissues to reach the levels at which DNA damage has been observed in animals and in vitro. The use of chromium supplements for extended periods or in excess dosages should be reevaluated in terms of these established models because the possible long-term biological effects of chromium accumulation in humans are poorly understood.

AB - It has been proposed that 90% of American's diets are deficient in the trace essential mineral chromium. Several chromium(III) dietary supplements are currently available to alleviate this deficiency. We show here that the same pharmacokinetic models that have been used to quantitate absorption of chromium(III) in humans predict that ingested chromium(III) will accumulate and be retained in human tissues for extended periods. Calculations were carried out with the popular supplement chromium picolinate as an example, but may be applied to any chromium(III) complex. Results from these calculations were compared to clinical data obtained from chromium(III) absorption/retention studies in humans. The models predict that chromium(III) can accumulate in human tissues to reach the levels at which DNA damage has been observed in animals and in vitro. The use of chromium supplements for extended periods or in excess dosages should be reevaluated in terms of these established models because the possible long-term biological effects of chromium accumulation in humans are poorly understood.

KW - absorption

KW - chromium

KW - picolinic acid

KW - supplementation

KW - toxicity

UR - http://www.scopus.com/inward/record.url?scp=0029592799&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029592799&partnerID=8YFLogxK

M3 - Article

C2 - 8529846

AN - SCOPUS:0029592799

VL - 9

SP - 1650

EP - 1657

JO - FASEB Journal

JF - FASEB Journal

SN - 0892-6638

IS - 15

ER -