A mouse model of binge alcohol consumption and Burkholderia infection

Victor Jimenez, Ryan Moreno, Erik Settles, Bart J. Currie, Paul S Keim, Fernando P Monroy

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Binge drinking, an increasingly common form of alcohol consumption, is associated with increased mortality and morbidity; yet, its effects on the immune system's ability to defend against infectious agents are poorly understood. Burkholderia pseudomallei, the causative agent of melioidosis can occur in healthy humans, yet binge alcohol use is progressively being recognized as a major risk factor. Although our previous studies demonstrated that binge alcohol exposure results in reduced alveolar macrophage function and increased Burkholderia virulence in vitro, no experimental studies have investigated the outcomes of binge alcohol on Burkholderia spp. infection in vivo.

Original languageEnglish (US)
Article numbere0208061
JournalPLoS One
Volume13
Issue number11
DOIs
StatePublished - Nov 1 2018

    Fingerprint

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this