A mouse model of binge alcohol consumption and Burkholderia infection

Victor Jimenez, Ryan Moreno, Erik Settles, Bart J. Currie, Paul S Keim, Fernando P Monroy

Research output: Contribution to journalArticle

Abstract

Binge drinking, an increasingly common form of alcohol consumption, is associated with increased mortality and morbidity; yet, its effects on the immune system's ability to defend against infectious agents are poorly understood. Burkholderia pseudomallei, the causative agent of melioidosis can occur in healthy humans, yet binge alcohol use is progressively being recognized as a major risk factor. Although our previous studies demonstrated that binge alcohol exposure results in reduced alveolar macrophage function and increased Burkholderia virulence in vitro, no experimental studies have investigated the outcomes of binge alcohol on Burkholderia spp. infection in vivo.

Original languageEnglish (US)
Article numbere0208061
JournalPLoS One
Volume13
Issue number11
DOIs
StatePublished - Nov 1 2018

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Burkholderia Infections
Burkholderia
Alcohol Drinking
alcohols
animal models
Alcohols
Burkholderia pseudomallei
infection
Melioidosis
Binge Drinking
binging
Aptitude
Alveolar Macrophages
morbidity
Virulence
immune system
Immune system
Immune System
macrophages
virulence

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

A mouse model of binge alcohol consumption and Burkholderia infection. / Jimenez, Victor; Moreno, Ryan; Settles, Erik; Currie, Bart J.; Keim, Paul S; Monroy, Fernando P.

In: PLoS One, Vol. 13, No. 11, e0208061, 01.11.2018.

Research output: Contribution to journalArticle

Jimenez, Victor ; Moreno, Ryan ; Settles, Erik ; Currie, Bart J. ; Keim, Paul S ; Monroy, Fernando P. / A mouse model of binge alcohol consumption and Burkholderia infection. In: PLoS One. 2018 ; Vol. 13, No. 11.
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