• 1542 Citations
  • 24 h-Index
1982 …2019
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Ligands Medicine & Life Sciences
Immunoglobulin E Medicine & Life Sciences
Receptor Aggregation Medicine & Life Sciences
Cell Surface Receptors Medicine & Life Sciences
IgE Receptors Medicine & Life Sciences
Kinetics Chemical Compounds
Proteins Medicine & Life Sciences
Pancreatic Neoplasms Medicine & Life Sciences

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Projects 1982 2018

Receptor Aggregation
Mast Cells
Ligands
Immunoglobulin E
Signal Transduction

NATIONAL FLOW CYTOMETRY AND SORTING RESEARCH RESOURCE

Posner, R. G., Waldren, C., Martin, D., Raju, M., Lehman, J., Bartholdi, M., Stallings, R., Stewart, C., Crawford, B., Crissman, H., Unkefer, P., Hoekstra, M., Leffert, H., Erickson, R., Priebe, W., Cobo, J., Shen, B., Waldo, G., Kunz, L., Smith, P., Sailer, B., Evenson, D., Narayanan, P., Yvonne, L., Burma, S., Vallarino, L., Smith, P., Burma, S., Phillips, A., Frangos, J., Smith, D., Capecchi, M., Vitharana, S., Ruscetti, T., Bradbury, A., Graves, S., Tsien, R., Waldo, G., Goodwin, P. M., Wilder, M., Hong, C., Jiang, Y., Espy, M. A., Mourant, J., Naivar, M., Gustafson, J., Juhong, L., Schaad, N., Pavlik, P., Serrano, E., Sanders, C., Kaduchak, G., Malloy, K., Gorenstein, D., Kuske, C., Sevick-Muraca, E., Chun, L., Applegate, R., Doorn, J., Goddard, G., Dichosa, A., Hong-Geller, E., Lillo, R., D'Anna, J. O. E., Steinkamp John, [. V., Lagarias, J. C., Kraakman-van der Zwet, M., Cornforth, M. N., Keller, R. A., Lopez, G. P., Novo, P. M., Goolsby, C. L., Hall, L., Th, J., Habbersett, R., D'Anna, J., Sklar, L. A., Freyer, J., Nolan, J., Zbigniew, D., Salzman, G., Hedley, D., Kraemer, P., Lehnert, B., Cram, S., Bradbury, E. M., Darzynkiewicz, Z., Martin, J., Steinkamp, J., Chen, D., Keng, P., Bell Prince, C., Marrone, B., Jett, J., Cram, S., Darzynkiewicz, Z., Chen, D., Habbersett, R., Cram, S., Sklar, L. A., Smith, P. & Steinkamp John

National Institutes of Health

7/1/823/31/13

Project: Research project

Receptor Aggregation
Immunoglobulin E
Ligands
Protein-Tyrosine Kinases
Signal Transduction
Receptor Aggregation
Immunoglobulin E
Signal transduction
IgE Receptors
Agglomeration

Hardening Software for Rule-based Modeling.

Posner, R. G., Hlavacek, W. S. & Hlavacek, W. S.

National Institutes of Health

8/1/144/30/18

Project: Research project

Hardening
Phosphorylation
Simulators
Bifurcation (mathematics)
Distributed computer systems

Research Output 1985 2019

  • 1542 Citations
  • 24 h-Index
  • 47 Article
  • 2 Conference contribution
  • 1 Chapter

Modeling cell line-specific recruitment of signaling proteins to the insulin-like growth factor 1 receptor

Erickson, K. E., Rukhlenko, O. S., Shahinuzzaman, M., Slavkova, K. P., Lin, Y. T., Suderman, R., Stites, E. C., Anghel, M., Posner, R. G., Barua, D., Kholodenko, B. N. & Hlavacek, W. S., Jan 1 2019, In : PLoS Computational Biology. 15, 1, p. e1006706

Research output: Contribution to journalArticle

Somatomedin Receptors
Insulin
Growth Factors
Receptor
Phosphotyrosine
4 Citations (Scopus)

Dissecting RAF Inhibitor Resistance by Structure-based Modeling Reveals Ways to Overcome Oncogenic RAS Signaling

Rukhlenko, O. S., Khorsand, F., Krstic, A., Rozanc, J., Alexopoulos, L. G., Rauch, N., Erickson, K. E., Hlavacek, W. S., Posner, R. G., Gómez-Coca, S., Rosta, E., Fitzgibbon, C., Matallanas, D., Rauch, J., Kolch, W. & Kholodenko, B. N., Jan 1 2018, (Accepted/In press) In : Cell Systems.

Research output: Contribution to journalArticle

MAP Kinase Signaling System
Drug Design
Mitogen-Activated Protein Kinase Kinases
Dimerization
Post Translational Protein Processing

New insights into RAS biology reinvigorate interest in mathematical modeling of RAS signaling

Erickson, K. E., Rukhlenko, O. S., Posner, R. G., Hlavacek, W. S. & Kholodenko, B. N., Jan 1 2018, (Accepted/In press) In : Seminars in Cancer Biology.

Research output: Contribution to journalArticle

Neoplasms
Protein Isoforms
Technology
Pharmaceutical Preparations
Genes

Using both qualitative and quantitative data in parameter identification for systems biology models

Mitra, E. D., Dias, R., Posner, R. G. & Hlavacek, W. S., Dec 1 2018, In : Nature Communications. 9, 1, 3901.

Research output: Contribution to journalArticle

parameter identification
Systems Biology
biology
Identification (control systems)
Yeasts

A phase 2 trial of personalized cytotoxic therapy based on tumor immunohistochemistry in previously treated metastatic pancreatic cancer patients

Ramanathan, R. K., Weiss, G. J., Posner, R. G., Rajeshkumar, N. V., Jameson, G., Aziz, M., Hoering, A., Bolejack, V., Maitra, A., Fulk, M., Stites, E. C., Hlavacek, W. S., Gatalica, Z., Xiu, J., Hidalgo, M., Von Hoff, D. D. & Barrett, M. T., Dec 1 2017, In : Journal of Gastrointestinal Oncology. 8, 6, p. 925-935 11 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Immunohistochemistry
Neoplasms
Biopsy
irinotecan