• 1542 Citations
  • 24 h-Index
1982 …2019
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Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

Ligands Medicine & Life Sciences
Immunoglobulin E Medicine & Life Sciences
Receptor Aggregation Medicine & Life Sciences
Cell Surface Receptors Medicine & Life Sciences
IgE Receptors Medicine & Life Sciences
Kinetics Chemical Compounds
Proteins Medicine & Life Sciences
Pancreatic Neoplasms Medicine & Life Sciences

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Projects 1982 2018

Receptor Aggregation
Mast Cells
Immunoglobulin E
Signal Transduction


Posner, R. G., Waldren, C., Martin, D., Raju, M., Lehman, J., Bartholdi, M., Stallings, R., Stewart, C., Crawford, B., Crissman, H., Unkefer, P., Hoekstra, M., Leffert, H., Erickson, R., Priebe, W., Cobo, J., Shen, B., Waldo, G., Kunz, L., Smith, P., Sailer, B., Evenson, D., Narayanan, P., Yvonne, L., Burma, S., Vallarino, L., Smith, P., Burma, S., Phillips, A., Frangos, J., Smith, D., Capecchi, M., Vitharana, S., Ruscetti, T., Bradbury, A., Graves, S., Tsien, R., Waldo, G., Goodwin, P. M., Wilder, M., Hong, C., Jiang, Y., Espy, M. A., Mourant, J., Naivar, M., Gustafson, J., Juhong, L., Schaad, N., Pavlik, P., Serrano, E., Sanders, C., Kaduchak, G., Malloy, K., Gorenstein, D., Kuske, C., Sevick-Muraca, E., Chun, L., Applegate, R., Doorn, J., Goddard, G., Dichosa, A., Hong-Geller, E., Lillo, R., D'Anna, J. O. E., Steinkamp John, [. V., Lagarias, J. C., Kraakman-van der Zwet, M., Cornforth, M. N., Keller, R. A., Lopez, G. P., Novo, P. M., Goolsby, C. L., Hall, L., Th, J., Habbersett, R., D'Anna, J., Sklar, L. A., Freyer, J., Nolan, J., Zbigniew, D., Salzman, G., Hedley, D., Kraemer, P., Lehnert, B., Cram, S., Bradbury, E. M., Darzynkiewicz, Z., Martin, J., Steinkamp, J., Chen, D., Keng, P., Bell Prince, C., Marrone, B., Jett, J., Cram, S., Darzynkiewicz, Z., Chen, D., Habbersett, R., Cram, S., Sklar, L. A., Smith, P. & Steinkamp John

National Institutes of Health


Project: Research project

Receptor Aggregation
Immunoglobulin E
Protein-Tyrosine Kinases
Signal Transduction
Receptor Aggregation
Immunoglobulin E
Signal transduction
IgE Receptors

Hardening Software for Rule-based Modeling.

Posner, R. G., Hlavacek, W. S. & Hlavacek, W. S.

National Institutes of Health


Project: Research project

Bifurcation (mathematics)
Distributed computer systems

Research Output 1985 2019

  • 1542 Citations
  • 24 h-Index
  • 47 Article
  • 2 Conference contribution
  • 1 Chapter

Modeling cell line-specific recruitment of signaling proteins to the insulin-like growth factor 1 receptor

Erickson, K. E., Rukhlenko, O. S., Shahinuzzaman, M., Slavkova, K. P., Lin, Y. T., Suderman, R., Stites, E. C., Anghel, M., Posner, R. G., Barua, D., Kholodenko, B. N. & Hlavacek, W. S., Jan 1 2019, In : PLoS Computational Biology. 15, 1, p. e1006706

Research output: Contribution to journalArticle

Somatomedin Receptors
Growth Factors
4 Citations (Scopus)

Dissecting RAF Inhibitor Resistance by Structure-based Modeling Reveals Ways to Overcome Oncogenic RAS Signaling

Rukhlenko, O. S., Khorsand, F., Krstic, A., Rozanc, J., Alexopoulos, L. G., Rauch, N., Erickson, K. E., Hlavacek, W. S., Posner, R. G., Gómez-Coca, S., Rosta, E., Fitzgibbon, C., Matallanas, D., Rauch, J., Kolch, W. & Kholodenko, B. N., Jan 1 2018, (Accepted/In press) In : Cell Systems.

Research output: Contribution to journalArticle

MAP Kinase Signaling System
Drug Design
Mitogen-Activated Protein Kinase Kinases
Post Translational Protein Processing

New insights into RAS biology reinvigorate interest in mathematical modeling of RAS signaling

Erickson, K. E., Rukhlenko, O. S., Posner, R. G., Hlavacek, W. S. & Kholodenko, B. N., Jan 1 2018, (Accepted/In press) In : Seminars in Cancer Biology.

Research output: Contribution to journalArticle

Protein Isoforms
Pharmaceutical Preparations

Using both qualitative and quantitative data in parameter identification for systems biology models

Mitra, E. D., Dias, R., Posner, R. G. & Hlavacek, W. S., Dec 1 2018, In : Nature Communications. 9, 1, 3901.

Research output: Contribution to journalArticle

parameter identification
Systems Biology
Identification (control systems)

A phase 2 trial of personalized cytotoxic therapy based on tumor immunohistochemistry in previously treated metastatic pancreatic cancer patients

Ramanathan, R. K., Weiss, G. J., Posner, R. G., Rajeshkumar, N. V., Jameson, G., Aziz, M., Hoering, A., Bolejack, V., Maitra, A., Fulk, M., Stites, E. C., Hlavacek, W. S., Gatalica, Z., Xiu, J., Hidalgo, M., Von Hoff, D. D. & Barrett, M. T., Dec 1 2017, In : Journal of Gastrointestinal Oncology. 8, 6, p. 925-935 11 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms